Evidence map›Paper›PMID 32998761›Full record

ArticleTrials2020

Evaluation of the effect of Cooled HaEmodialysis on Cognitive function in patients suffering with end-stage KidnEy Disease (E-CHECKED): feasibility randomised control trial protocol.

Indranil Dasgupta, Aghogho Odudu, Jyoti Baharani, Niall Fergusson, Helen Griffiths, John Harrison, Paul Maruff, G Neil Thomas, Gavin Woodhall, Samir Youseff and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03645733 (Evaluation of the Effect of Cooled Haemodialysis on Cognitive Function in Patients Suffering With End-stage Kidney Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03645733 naunknown statusnot on this map

Evaluation of the Effect of Cooled Haemodialysis on Cognitive Function in Patients Suffering With End-stage Kidney Disease: Feasibility Study

TypeinterventionalSponsorHeart of England NHS TrustRan2017 to 2020Enrolled90ConditionsCognitive ImpairmentArmsLower Temperature Group
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Dialysis and cognitive impairment.Nature reviews. Nephrology · 2025
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Indranil DasguptaRenal Unit, Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK. indranil.dasgupta@uhb.nhs.uk.ORCID http://orcid.org/0000-0002-7448-2677
Aghogho OduduDivision of Cardiovascular Sciences, University of Manchester, Manchester, UK.
Jyoti BaharaniRenal Unit, Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK.
Niall FergussonDepartment of Care of the Elderly, Heartlands Hospital, Birmingham, UK.
Helen GriffithsFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
John HarrisonInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Paul MaruffCogstate Limited, Melbourne, Australia.
G Neil ThomasInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Gavin WoodhallSchool of Neuropharmacology, Aston University, Birmingham, UK.
Samir YouseffPatient Representative, Birmingham, UK.
George TadrosDepartment of Old Age Psychiatry, Heartlands Hospital, Birmingham, UK.
Aston University · GBHeartlands Hospital · GBBirmingham Community Healthcare NHS Trust · GBKing's College London · GBUniversity of Birmingham · GBUniversity of Manchester · GBUniversity of Surrey · GBUniversity of Warwick · GB

Funding

Department of Health PB-PG-1215-20008Research for Patient Benefit Programme PB-PG-1215-20008
6 · The paper itself

Abstract

backgroundCognitive impairment is common in haemodialysis (HD) patients and is associated independently with depression and mortality. This association is poorly understood, and no intervention is proven to slow cognitive decline. There is evidence that cooler dialysis fluid (dialysate) may slow white matter changes in the brain, but no study has investigated the effect of cooler dialysate on cognition. This study addresses whether cooler dialysate can prevent the decline in cognition and improve quality of life (QOL) in HD patients.

methodsThis is a multi-site prospective randomised, double-blinded feasibility trial.

settingFour HD units in the UK. PARTICIPANTS AND

interventionsNinety HD patients randomised (1:1) to standard care (dialysate temperature 36.5 °C) or intervention (dialysate temperature 35 °C) for 12 months. PRIMARY OUTCOME MEASURE: Change in cognition using the Montreal Cognitive Assessment (MoCA). SECONDARY OUTCOME MEASURES: Recruitment and attrition rates, reasons for non-recruitment, frequency of intradialytic hypotension, depressive symptom scores, patient and carers burden, a detailed computerised cognitive test and QOL assessments. ANALYSIS: mixed method approach, utilising measurement of cognition, questionnaires, physiological measurements and semi-structured interviews. DISCUSSION: The results of this feasibility trial will inform the design of a future adequately powered substantive trial investigating the effect of dialysate cooling on prevention and/or slowing in cognitive decline in patients undergoing haemodialysis using a computerised battery of neuro-cognitive tests. The main hypothesis that would be tested in this future trial is that patients treated with regular conventional haemodialysis will have a lesser decline in cognitive function and a better quality of life over 1 year by using cooler dialysis fluid at 35 °C, versus a standard dialysis fluid temperature of 36.5 °C. This also should reflect in improvements in their abilities for activities of daily living and therefore reduce carers' burden. If successful, the treatment could be universally applied at no extra cost.

trial registrationClinicalTrials.gov NCT03645733 . Registered retrospectively on 24 August 2018.

Indexed as

Kidney Failure, ChronicQuality of LifeActivities of Daily LivingCognitionFeasibility StudiesHumansProspective StudiesRandomized Controlled Trials as TopicRenal DialysisRetrospective StudiesCognitionCognitive functionCold temperatureHaemodialysisHaemodialysis solutionsRandomised controlled trial

Identifiers

PMID32998761
PMCPMC7526411
OpenAlexW3090004247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.