Evidence map›Paper›PMID 32998551›Full record

ArticleThe American journal of psychiatry2020

Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents.

Anna R Docherty, Andrey A Shabalin, Emily DiBlasi, Eric Monson, Niamh Mullins, Daniel E Adkins, Silviu-Alin Bacanu, Amanda V Bakian, Sheila Crowell, Danli Chen and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022
    Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Suicidality phenotypes reflect both shared and distinct genetic factors.medRxiv : the preprint server for health sciences · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Mapping the genetic landscape of suicide risk: Insights from genomic SEM.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  19. Review
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Anna R DochertyDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Andrey A ShabalinDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Emily DiBlasiDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Eric MonsonDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Niamh MullinsDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Daniel E AdkinsDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Silviu-Alin BacanuDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Amanda V BakianDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Sheila CrowellDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Danli ChenDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Todd M DarlingtonDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
William B CallorDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Erik D ChristensenDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Douglas GrayDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Brooks KeeshinDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Michael KleinDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
John S AndersonDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Leslie JerominskiDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Caroline HaywardDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
David J PorteousDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Andrew McIntoshDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Qingqin LiDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).
Hilary CoonDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City (Docherty, Shabalin, DiBlasi, Monson, Adkins, Bakian, Crowell, Chen, Darlington, Gray, Anderson, Jerominski, Coon); Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City (Docherty); Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond (Docherty, Bacanu); Department of Genetics and Genomic Sciences, Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York (Mullins); Department of Psychology, University of Utah, Salt Lake City (Crowell); Utah State Office of the Medical Examiner, Utah Department of Health, Salt Lake City (Callor, Christensen); Mental Illness Research, Education, and Clinical Center, Veterans Integrated Service Network 19, George E. Whalen Department of Veterans Affairs Medical Center, Salt Lake City (Gray); Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (Keeshin); Health Sciences Center Core Research Facility, University of Utah, Salt Lake City (Klein); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Hayward, Porteous, McIntosh); Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, U.K. (Porteous, McIntosh); and Janssen Research and Development, Neuroscience Therapeutic Area, Titusville, N.J. (Li).

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CORNELIA M ULRICH · 1986 to 2026
$72.6M
Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Prediction of suicide death using EHR and polygenic risk scoresR01MH123489 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI COON, HILARY · 2020 to 2025
$4.2M
Genetic analysis of high-risk Utah suicide pedigreesR01MH099134 · NIMH · UNIVERSITY OF UTAH · PI COON, HILARY · 2013 to 2017
$3.9M
Genome-Wide Association Analysis of Suicide DeathR01MH123619 · NIMH · UNIVERSITY OF UTAH · PI DOCHERTY, ANNA R. · 2020 to 2024
$3.2M
Genetic risk discovery using WGS from a population-based resource of 10,000 suicide deaths with DNAR01MH122412 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Hilary Coon · 2020 to 2026
$2.7M
Modeling Dimensionality and Genetic Heterogeneity in SchizophreniaK01MH109765 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI DOCHERTY, ANNA R. · 2016 to 2019
$675k
Integrating Genomic and Environmental Perspectives on Internalizing DisordersK01MH093731 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI ADKINS, DANIEL E · 2011 to 2015
$649k
Medical Research Council MC_UU_00007/10NCATS NIH HHS UL1 TR002538NCI NIH HHS P30 CA042014NIMH NIH HHS K01 MH093731NIMH NIH HHS K01 MH109765NIMH NIH HHS R01 MH099134NIMH NIH HHS R01 MH122412NIMH NIH HHS R01 MH123489NIMH NIH HHS R01 MH123619Wellcome Trust
6 · The paper itself

Abstract

objectiveDeath by suicide is a highly preventable yet growing worldwide health crisis. To date, there has been a lack of adequately powered genomic studies of suicide, with no sizable suicide death cohorts available for analysis. To address this limitation, the authors conducted the first comprehensive genomic analysis of suicide death using previously unpublished genotype data from a large population-ascertained cohort.

methodsThe analysis sample comprised 3,413 population-ascertained case subjects of European ancestry and 14,810 ancestrally matched control subjects. Analytical methods included principal component analysis for ancestral matching and adjusting for population stratification, linear mixed model genome-wide association testing (conditional on genetic-relatedness matrix), gene and gene set-enrichment testing, and polygenic score analyses, as well as single-nucleotide polymorphism (SNP) heritability and genetic correlation estimation using linkage disequilibrium score regression.

resultsGenome-wide association analysis identified two genome-wide significant loci (involving six SNPs: rs34399104, rs35518298, rs34053895, rs66828456, rs35502061, and rs35256367). Gene-based analyses implicated 22 genes on chromosomes 13, 15, 16, 17, and 19 (q<0.05). Suicide death heritability was estimated at an h

conclusionsMultiple genome-wide significant loci and genes were identified and polygenic score prediction of suicide death case-control status was demonstrated, adjusting for ancestry, in independent training and test sets. Additionally, the suicide death sample was found to have increased genetic risk for behavioral disinhibition, major depressive disorder, depressive symptoms, autism spectrum disorder, psychosis, and alcohol use disorder compared with the control sample.

Indexed as

AdultCase-Control StudiesFemaleGenome, HumanGenome-Wide Association StudyGenotyping TechniquesHumansLinkage DisequilibriumMaleMultifactorial InheritancePolymorphism, Single NucleotidePrincipal Component AnalysisScotlandSex FactorsSuicide, CompletedUtahGWASPolygenic ScoreSuicide

Identifiers

PMID32998551
PMCPMC7872505

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