Evidence map›Paper›PMID 32998426›Full record

ArticleMetabolites2020

Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans.

Angie S Xiang, Corey Giles, Rebecca K C Loh, Melissa F Formosa, Nina Eikelis, Gavin W Lambert, Peter J Meikle, Bronwyn A Kingwell, Andrew L Carey

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Changes in brown adipose tissue lipid mediator signatures with aging, obesity, and DHA supplementation in female mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Angie S XiangMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, Australia.
Corey GilesMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, Australia.ORCID 0000-0002-6050-1259
Rebecca K C LohMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, Australia.
Melissa F FormosaMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, Australia.
Nina EikelisIverson Health Innovation Research Institute, Swinburne Institute of Technology, Melbourne 3122, Australia.
Gavin W LambertIverson Health Innovation Research Institute, Swinburne Institute of Technology, Melbourne 3122, Australia.
Peter J MeikleMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, Australia.ORCID 0000-0002-2593-4665
Bronwyn A KingwellMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, Australia.
Andrew L CareyMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, Australia.ORCID 0000-0003-3452-1501
Baker Heart and Diabetes Institute · AUSwinburne University of Technology · AU

Funding

National Health and Medical Research Council -
6 · The paper itself

Abstract

Brown adipose tissue (BAT) activation is a possible therapeutic strategy to increase energy expenditure and improve metabolic homeostasis in obesity. Recent studies have revealed novel interactions between BAT and circulating lipid species-in particular, the non-esterified fatty acid (NEFA) and oxylipin lipid classes. This study aimed to identify individual lipid species that may be associated with cold-stimulated BAT activity in humans. A panel of 44 NEFA and 41 oxylipin species were measured using mass-spectrometry-based lipidomics in the plasma of fourteen healthy male participants before and after 90 min of mild cold exposure. Lipid measures were correlated with BAT activity measured via

Indexed as

BATbrown adipose tissueDHAEPAfatty acidsfish oillipidomicsmass spectrometryNEFAobesityoxylipin

Identifiers

PMID32998426
PMCPMC7601733
OpenAlexW3087772571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.