Evidence map›Paper›PMID 32998418›Full record

ArticleAntioxidants (Basel, Switzerland)2020

Microvesicle Formation Induced by Oxidative Stress in Human Erythrocytes.

Julia Sudnitsyna, Elisaveta Skverchinskaya, Irina Dobrylko, Elena Nikitina, Stepan Gambaryan, Igor Mindukshev

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
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  6. Cytoprotective Potential ofInternational journal of molecular sciences · 2025
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  14. Chloride Gradient Is Involved in Ammonium Influx in Human Erythrocytes.International journal of molecular sciences · 2024
    Article
  15. Article
  16. Review
  17. Current pharmaceutical design · 2024
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Julia SudnitsynaCenter for Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Kosygina st., 4, 119991 Moscow, Russia.ORCID 0000-0002-5322-7044
Elisaveta SkverchinskayaSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez pr., 44, 194223 Saint-Petersburg, Russia.ORCID 0000-0001-9587-6619
Irina DobrylkoSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez pr., 44, 194223 Saint-Petersburg, Russia.
Elena NikitinaSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez pr., 44, 194223 Saint-Petersburg, Russia.ORCID 0000-0001-8250-0954
Stepan GambaryanSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez pr., 44, 194223 Saint-Petersburg, Russia.
Igor MindukshevSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez pr., 44, 194223 Saint-Petersburg, Russia.ORCID 0000-0001-5978-2105
Institute of Evolutionary Physiology and Biochemistry · RUCenter for Theoretical Problems of Physicochemical Pharmacology · RU

Funding

Russian Fund for Basic Researches 19-315-60015 to J.S.State Assignment of Ministry of Science and Higher Education of the Russian Federation AAAA-A18-118012290371-3 to E.S., I.D., E.R.N., S.G. and I.M.
6 · The paper itself

Abstract

Extracellular vesicles (EVs) released by different cell types play an important role in many physiological and pathophysiological processes. In physiological conditions, red blood cell (RBC)-derived EVs compose 4-8% of all circulating EVs, and oxidative stress (OS) as a consequence of different pathophysiological conditions significantly increases the amount of circulated RBC-derived EVs. However, the mechanisms of EV formation are not yet fully defined. To analyze OS-induced EV formation and RBC transformations, we used flow cytometry to evaluate cell esterase activity, caspase-3 activity, and band 3 clustering. Band 3 clustering was additionally analyzed by confocal microscopy. Two original laser diffraction-based approaches were used for the analysis of cell deformability and band 3 activity. Hemoglobin species were characterized spectrophotometrically. We showed that cell viability in

Indexed as

band 3calcium ionophore A23187erythrocytesmicroparticlesnitric oxide donoroxidative stresstert-Bytyl hydroperoxide t-BOOHvesiculation

Identifiers

PMID32998418
PMCPMC7650597
OpenAlexW3081846406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.