Evidence map›Paper›PMID 32998413›Full record

ArticleInternational journal of molecular sciences2020

Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells.

Stephan De Waard, Jérôme Montnach, Barbara Ribeiro, Sébastien Nicolas, Virginie Forest, Flavien Charpentier, Matteo Elia Mangoni, Nathalie Gaborit, Michel Ronjat, Gildas Loussouarn and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Selective activation of tetrodotoxin-sensitive sodium channels by AaH-II drives arrhythmogenic late Na+ current in the heart.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Peptides for Health Benefits 2020.International journal of molecular sciences · 2022
    Article
  7. Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Stephan De WaardL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Jérôme MontnachL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Barbara RibeiroL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Sébastien NicolasL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Virginie ForestL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Flavien CharpentierL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Matteo Elia MangoniLabEx Ion Channels, Science & Therapeutics, F-06560 Valbonne, France.
Nathalie GaboritL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Michel RonjatL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Gildas LoussouarnL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Patricia LemarchandL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Michel De WaardL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.ORCID 0000-0002-2782-9615
Centre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR-11-LABX-0015Agence Nationale de la Recherche ANR-15-CE14-0004-02Région Pays de la Loire 2016-11092/11093
6 · The paper itself

Abstract

I

Indexed as

Action PotentialsAnti-Arrhythmia AgentsCalciumCalcium ChannelsCell DifferentiationERG1 Potassium ChannelHEK293 CellsHumansInduced Pluripotent Stem CellsIon TransportLong QT SyndromeModels, BiologicalMyocytes, CardiacPatch-Clamp TechniquesPhenethylaminesPiperidinesAnti-Arrhythmia AgentsBeKm-1 toxinCalciumCalcium ChannelsdofetilideE 4031ERG1 Potassium ChannelKCNH2 protein, humanPhenethylaminesPiperidinesPotassiumPotassium Channel BlockersPyridinesScorpion VenomsSulfonamidesBeKm-1hERGhiPS-cardiomyocytesLQTS

Identifiers

PMID32998413
PMCPMC7582727
OpenAlexW3089170894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.