Evidence map›Paper›PMID 32998395›Full record

ArticleJournal of fungi (Basel, Switzerland)2020

Ágata Nogueira D'Áurea Moura, Diane Sthefany Lima de Oliveira, Verenice Paredes, Letícia Barboza Rocha, Fabiana Freire Mende de Oliveira, Gustavo Meirelles Lessa, Juan Fernando Riasco-Palacios, Arturo Casadevall, Patrícia Albuquerque, Maria Sueli Soares Felipe and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. The Response ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  4. Review
  5. Updates inJournal of fungi (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ágata Nogueira D'Áurea MouraInstitute of Tropical Medicine, Department of Dermatology, Faculty of Medicine, University of São Paulo, São Paulo 05403-000, SP, Brazil.ORCID 0000-0003-0480-5028
Diane Sthefany Lima de OliveiraInstitute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-2655-4672
Verenice ParedesKaran Technologies Research and Development, Brasília 70632-200, DF, Brazil.
Letícia Barboza RochaBacteriology Laboratory, Butantan Institute, São Paulo 05503-900, SP, Brazil.ORCID 0000-0001-7832-058X
Fabiana Freire Mende de OliveiraFaculty of Medicine, University of Brasília, Brasília 70910-900, DF, Brazil.
Gustavo Meirelles LessaFaculty of Medicine, University of Brasília, Brasília 70910-900, DF, Brazil.
Juan Fernando Riasco-PalaciosFaculty of Medicine, University of Brasília, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-9170-1034
Arturo CasadevallDepartment of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-9402-9167
Patrícia AlbuquerqueFaculty of Ceilândia, University of Brasília, Brasília 72220-275, DF, Brazil.ORCID 0000-0001-8160-7784
Maria Sueli Soares FelipeInstitute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.
Roxane Maria Fontes PiazzaBacteriology Laboratory, Butantan Institute, São Paulo 05503-900, SP, Brazil.
André Moraes NicolaKaran Technologies Research and Development, Brasília 70632-200, DF, Brazil.ORCID 0000-0001-8656-5835
Universidade de Brasília · BRInstituto Butantan · BRJohns Hopkins University · USUniversidade de São Paulo · BR

Funding

Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Conselho Nacional de Desenvolvimento Científico e Tecnológico 437484/2018-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/17178-2Fundação de Apoio à Pesquisa do Distrito Federal 0193.001048/2015Fundação de Apoio à Pesquisa do Distrito Federal 193.001.533/2016NHLBI NIH HHS R01 HL059842
6 · The paper itself

Abstract

Paracoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, but also modulate the host's antifungal immunity. In this work we show the generation of and promising results with an mAb against Heat Shock Protein (HSP)90, a molecular chaperone that is an important virulence factor in fungi. Using recombinant

Indexed as

HSP90monoclonal antibodyParacoccidioides spp.

Identifiers

PMID32998395
PMCPMC7712200
OpenAlexW3088028582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.