Evidence map›Paper›PMID 32998356›Full record

ArticleViruses2020

Chicken Astrovirus (CAstV) Molecular Studies Reveal Evidence of Multiple Past Recombination Events in Sequences Originated from Clinical Samples of White Chick Syndrome (WCS) in Western Canada.

Victor Palomino-Tapia, Darko Mitevski, Tom Inglis, Frank van der Meer, Emily Martin, Marina Brash, Chantale Provost, Carl A Gagnon, Mohamed Faizal Abdul-Careem

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 36 citations in OpenAlex.

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  14. Pathogenesis of Chicken Astrovirus Related Illnesses.Frontiers in veterinary science · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Victor Palomino-TapiaDepartment of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Health Research Innovation Center 2C53, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.ORCID 0000-0002-1367-7403
Darko MitevskiPoultry Health Services, 1-4 East Lake Ave NE, Airdrie, AB T4A 2G8, Canada.
Tom InglisThe Institute of Applied Poultry Technologies, 201-151 East Lake Blvd, Airdrie, AB T4A 2G1, Canada.
Frank van der MeerDepartment of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Health Research Innovation Center 2C53, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Emily MartinAnimal Health Laboratory, University of Guelph, Guelph, ON N1H 6R8, Canada.
Marina BrashAnimal Health Laboratory, University of Guelph, Guelph, ON N1H 6R8, Canada.
Chantale ProvostSwine and poultry infectious diseases research center (CRIPA Fonds de Recherche du Quebec), Molecular Diagnostic Laboratory, Faculty of veterinary medicine, University of Montreal, 3200 Sicotte, Saint-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0002-6674-1157
Carl A GagnonSwine and poultry infectious diseases research center (CRIPA Fonds de Recherche du Quebec), Molecular Diagnostic Laboratory, Faculty of veterinary medicine, University of Montreal, 3200 Sicotte, Saint-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0003-4528-541X
Mohamed Faizal Abdul-CareemDepartment of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Health Research Innovation Center 2C53, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
University of Calgary · CAUniversité de Montréal · CAUniversity of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we aimed to molecularly characterize 14 whole genome sequences of chicken astrovirus (CAstV) isolated from samples obtained from white chick syndrome (WCS) outbreaks in Western Canada during the period of 2014-2019. Genome sequence comparisons showed all these sequences correspond to the novel Biv group from which no confirmed representatives were published in GenBank. Molecular recombination analyses using recombination detection software (i.e., RDP5 and SimPlot) and phylogenetic analyses suggest multiple past recombination events in open reading frame (ORF)1a, ORF1b, and ORF2. Our findings suggest that recombination events and the accumulation of point mutations may have contributed to the substantial genetic variation observed in CAstV and evidenced by the current seven antigenic sub-clusters hitherto described. This is the first paper that describes recombination events in CAstV following analysis of complete CAstV sequences originated in Canada.

Indexed as

Recombination, GeneticAnimalsAstroviridae InfectionsAvastrovirusBase SequenceCanadaChickensGenome, ViralGenotypeLiverMolecular EpidemiologyOpen Reading FramesPhylogenyPoultry Diseaseschicken astrovirusmolecular epidemiologyrecombinationrunting-stunting syndromewhite chick syndromewhole genome sequencing

Identifiers

PMID32998356
PMCPMC7600043
OpenAlexW3088813247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.