ArticlePharmaceutics2020
Nitric Oxide-Releasing Thermoresponsive Pluronic F127/Alginate Hydrogel for Enhanced Antibacterial Activity and Accelerated Healing of Infected Wounds.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing.Drug delivery · 2026Article
- Preparation and Application of Sodium Alginate-Based Composite Hydrogels in Wound Dressings.Gels (Basel, Switzerland) · 2026Review
- Nitric Oxide-Releasing Thixotropic Hydrogels as Antibacterial and Hemocompatible Catheter Locks.ACS biomaterials science & engineering · 2026Article
- Smart hydrogel systems for skin fibrosis: rational design, mechanisms and therapeutic applications.Regenerative biomaterials · 2026Review
- Exploration of recent advancements of nanoparticle-based therapeutics emphasis on diabetic-related chronic wound management: a comprehensive review.Archives of pharmacal research · 2026Review
- Review
- Investigation of the susceptibility of clinical infection loads to nitric oxide antibacterial treatment.Nitric oxide : biology and chemistry · 2025Article
- Nitric Oxide-Releasing Topical Treatments for Cutaneous Melanoma.Molecular pharmaceutics · 2024Article
- Dual-Delivery Temperature-Sensitive Hydrogel with Antimicrobial and Anti-Inflammatory Brevilin A and Nitric Oxide for Wound Healing in Bacterial Infection.Gels (Basel, Switzerland) · 2024Article
- The Formulation and Characterization of Wound Dressing Releasing S-Nitrosoglutathione from Polyvinyl Alcohol/Borax Reinforced Carboxymethyl Chitosan Self-Healing Hydrogel.Pharmaceutics · 2024Article
- Electrospun Antimicrobial Drug Delivery Systems and Hydrogels Used for Wound Dressings.Pharmaceutics · 2024Review
- Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide.Macromolecular bioscience · 2024Review
- Gold-Enhanced Brachytherapy by a Nanoparticle-Releasing Hydrogel and 3D-Printed Subcutaneous Radioactive Implant Approach.Advanced healthcare materials · 2023Article
- Advances in Nitric Oxide-Releasing Hydrogels for Biomedical Applications.Current opinion in colloid & interface science · 2023Article
- Development potential of extracellular matrix hydrogels as hemostatic materials.Frontiers in bioengineering and biotechnology · 2023Review
- Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair.International journal of nanomedicine · 2023Review
- Antibacterial smart hydrogels: New hope for infectious wound management.Materials today. Bio · 2022Review
- Biomimetic gasotransmitter-releasing alginate beads for biocompatible antimicrobial therapy.Journal of colloid and interface science · 2022Article
- Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials.Materials today. Bio · 2022Review
- Current Advances in the Development of Hydrogel-Based Wound Dressings for Diabetic Foot Ulcer Treatment.Polymers · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Nitric oxide (NO), a highly reactive and lipophilic molecule, is one of the molecules present in the wound environment and implicated as an important regulator in all phases of wound healing. Here, we developed an NO-releasing thermoresponsive hydrogel (GSNO-PL/AL) composed of S-nitrosoglutathione (GSNO), pluronic F127 (PL), and alginate (AL) for the treatment of infected wounds. The GSNO was incorporated into the thermoresponsive PL/AL hydrogel, and differential scanning calorimetry techniques were used for the hydrogel characterization. The hydrogel was assessed by in vitro NO release, antibacterial activity, cytotoxicity, and wound-healing activity. The GSNO-PL/AL hydrogel demonstrated thermal responsiveness and biocompatibility, and it showed sustained NO release for 7 days. It also exhibited potent bactericidal activity against Gram-positive methicillin-resistant
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.