Evidence map›Paper›PMID 32998347›Full record

ArticleMicroorganisms2020

Elimination of Extracellular Adenosine Triphosphate for the Rapid Prediction of Quantitative Plate Counts in 24 h Time-Kill Studies against Carbapenem-Resistant Gram-Negative Bacteria.

Yiying Cai, Jonathan J Ng, Hui Leck, Jocelyn Q Teo, Jia-Xuan Goh, Winnie Lee, Tse-Hsien Koh, Thuan-Tong Tan, Tze-Peng Lim, Andrea L Kwa

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Variability in intrinsic drug tolerance inAntimicrobial agents and chemotherapy · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yiying CaiDepartment of Pharmacy, Singapore General Hospital, Singapore 169608, Singapore.
Jonathan J NgDepartment of Pharmacy, National University of Singapore, Singapore 117559, Singapore.
Hui LeckDepartment of Pharmacy, Singapore General Hospital, Singapore 169608, Singapore.
Jocelyn Q TeoDepartment of Pharmacy, Singapore General Hospital, Singapore 169608, Singapore.
Jia-Xuan GohDepartment of Pharmacy, Singapore General Hospital, Singapore 169608, Singapore.
Winnie LeeDepartment of Pharmacy, Singapore General Hospital, Singapore 169608, Singapore.
Tse-Hsien KohDepartment of Microbiology, Singapore General Hospital, Singapore 169856, Singapore.
Thuan-Tong TanDepartment of Infectious Diseases, Singapore General Hospital, Singapore 169856, Singapore.
Tze-Peng LimDepartment of Pharmacy, Singapore General Hospital, Singapore 169608, Singapore.ORCID 0000-0003-0610-687X
Andrea L KwaDepartment of Pharmacy, Singapore General Hospital, Singapore 169608, Singapore.
Singapore General Hospital · SGNational University of Singapore · SG

Funding

National Medical Research Council NMRC/CG/C005B/2017National Medical Research Council NMRC/CG/M011/2017National Medical Research Council TA16may012
6 · The paper itself

Abstract

Traditional in vitro time-kill studies (TKSs) require viable plating, which is tedious and time-consuming. We used ATP bioluminescence, with the removal of extracellular ATP (EC-ATP), as a surrogate for viable plating in TKSs against carbapenem-resistant Gram-negative bacteria (CR-GNB). Twenty-four-hour TKSs were conducted using eight clinical CR-GNB (two

Indexed as

apyraseATP bioluminescencetime-kill studies

Identifiers

PMID32998347
PMCPMC7599598
OpenAlexW3091523021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.