ArticlePLoS pathogens2020
C-type lectin-mediated microbial homeostasis is critical for Helicoverpa armigera larval growth and development.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- From sugar binders to diabetes fighters: the lectin saga of antihyperglycemic activity through systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- The C-type lectin AcCTL5 fromVirulence · 2026Article
- Transcriptional Reshaping of Bacteriocytes in the Aphid-Insects · 2026Article
- Helicoverpa armigera (Lepidoptera, Noctuidae) as a reservoir of potential polystyrene-degrading fungi.BMC microbiology · 2026Article
- Tryptophan catabolism reprograms immunity to prevent hemolymph bacterial dysbiosis and support molting in Spätzle-deficient Helicoverpa armigera larvae.BMC biology · 2026Article
- Transcriptomic and proteomic analyses of the immune responses of C-type lectin fromFrontiers in immunology · 2026Article
- Immune-Related Genes in the Honey Bee MiteInsects · 2025Article
- Identification and functional analysis of C-type lectin from mosquito Aedes albopictus in response to dengue virus infection.Parasites & vectors · 2024Article
- A CTL - Lys immune function maintains insect metamorphosis by preventing gut bacterial dysbiosis and limiting opportunistic infections.BMC biology · 2024Article
- Feeding Spodoptera exigua larvae with gut-derived Escherichia sp. increases larval juvenile hormone levels inhibiting cannibalism.Communications biology · 2023Article
- An entomopathogenic fungus exploits its host humoral antibacterial immunity to minimize bacterial competition in the hemolymph.Microbiome · 2023Article
- Immune functions of pattern recognition receptors in Lepidoptera.Frontiers in immunology · 2023Review
- Role of Lectin in the Response ofFrontiers in immunology · 2022Review
- Article
- Review
- A New C-Type Lectin Homolog SpCTL6 Exerting Immunoprotective Effect and Regulatory Role in Mud CrabFrontiers in immunology · 2021Article
- Proteomic Analyses Detect Higher Expression of C-Type Lectins in Imidacloprid-Resistant Colorado Potato BeetleInsects · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system of a host functions critically in shaping the composition of the microbiota, and some microbes are involved in regulating host endocrine system and development. However, whether the immune system acts on endocrine and development by shaping the composition of the microbiota remains unclear, and few molecular players or microbes involved in this process have been identified. In the current study, we found that RNA interference of a C-type lectin (HaCTL3) in the cotton bollworm Helicoverpa armigera suppresses ecdysone and juvenile hormone signaling, thus reducing larval body size and delaying pupation. Depletion of HaCTL3 also results in an increased abundance of Enterocuccus mundtii in the hemolymph, which may escape from the gut. Furthermore, HaCTL3 and its controlled antimicrobial peptides (attacin, lebocin, and gloverin) are involved in the clearance of E. mundtii from the hemolymph via phagocytosis or direct bactericidal activity. Injection of E. mundtii into larval hemocoel mimics HaCTL3-depleted phenotypes and suppresses ecdysone and juvenile hormone signaling. Taken together, we conclude that HaCTL3 maintains normal larval growth and development of H. armigera via suppressing the abundance of E. mundtii in the hemolymph. Our results provide the first evidence of an immune system acting on an endocrine system to modulate development via shaping the composition of microbiota in insect hemolymph. Thus, this study will deepen our understanding of the interaction between immunity and development.
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