Evidence map›Paper›PMID 32997686›Full record

ArticlePloS one2020

Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions.

Sarah Jeuthe, Josephine Kemna, Christoph Philipp Kemna, Dario Zocholl, Robert Klopfleisch, Rupert Palme, Clemens Kirschbaum, Christa Thoene-Reineke, Thomas Kammertoens

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In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah JeutheAnimal Facility of the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Josephine KemnaDepartment of Gene Therapy and Molecular Immunology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Christoph Philipp KemnaInstitute of Immunology, Charité Campus Berlin Buch, Berlin, Germany.
Dario ZochollInstitut für Biometrie und Klinische Epidemiologie, Charité Campus Mitte, Berlin, Germany.
Robert KlopfleischDepartment of Veterinary Medicine, Institute of Veterinary Pathology, Free University, Berlin, Germany.
Rupert PalmeUnit of Physiology, Pathophysiology and Experimental Endocrinology, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria.ORCID 0000-0001-9466-3662
Clemens KirschbaumDepartment of Psychology, Technical University, Dresden, Germany.
Christa Thoene-ReinekeDepartment of Veterinary Medicine, Institute for Animal Welfare, Animal Behavior and Laboratory Animal Science, Free University, Berlin, Germany.
Thomas KammertoensDepartment of Gene Therapy and Molecular Immunology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.ORCID 0000-0003-3309-5141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is controversially discussed whether immune-deficient mice experience severity in the absence of infection. Because a comprehensive analysis of the well-being of immune-deficient mice under specific pathogen free conditions is missing, we used a multi-parametric test analyzing, corticosterone, weight, nest building and facial expression over a period of 9 month to determine the well-being of two immune-deficient mouse lines (recombination activating gene 2- and interferon gamma receptor-deficient mice). We do not find evidence for severity when comparing immune-deficient mice to their heterozygous immune-competent littermates. Our data challenge the assumption that immune-deficiency per se regardless of housing conditions causes severity. Based on our study we propose to use objective non-invasive parameters determined by laboratory animal science for decisions concerning severity of immune-deficient mice.

Indexed as

AnimalsB-LymphocytesCorticosteroneDNA-Binding ProteinsHumansInfectionsInterferon-gammaInterferon gamma ReceptorKidneyMiceMice, SCIDPainReceptors, InterferonSignal TransductionTestosteroneT-LymphocytesCorticosteroneDNA-Binding ProteinsIFNG protein, mouseInterferon-gammaInterferon gamma ReceptorRag2 protein, mouseReceptors, InterferonTestosterone

Identifiers

PMID32997686
PMCPMC7526874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.