Evidence map›Paper›PMID 32997640›Full record

ArticleJMIR mHealth and uHealth2020

Syndromic Surveillance Insights from a Symptom Assessment App Before and During COVID-19 Measures in Germany and the United Kingdom: Results From Repeated Cross-Sectional Analyses.

Alicia Mehl, Francois Bergey, Caoimhe Cawley, Andreas Gilsdorf

Abstract read
In one paragraph

Article in JMIR mHealth and uHealth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
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  5. Detecting early signals of COVID-19 outbreaks in 2020 in small areas by monitoring healthcare utilisation databases: first lessons learned from the Italian Alert_CoV project.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  6. Article
  7. Article
  8. Chatbot use cases in the Covid-19 public health response.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
  9. Article
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  11. [Epidemiological approaches to address key research questions on COVID-19-an overview].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alicia Mehl *Department of Epidemiology & Public Health, Ada Health GmbH, Berlin, Germany.ORCID 0000-0001-9771-3135
Francois Bergey *Department of Epidemiology & Public Health, Ada Health GmbH, Berlin, Germany.ORCID 0000-0002-2405-8843
Caoimhe CawleyDepartment of Epidemiology & Public Health, Ada Health GmbH, Berlin, Germany.ORCID 0000-0001-7801-4806
Andreas GilsdorfDepartment of Epidemiology & Public Health, Ada Health GmbH, Berlin, Germany.ORCID 0000-0001-8572-2798

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnprecedented lockdown measures have been introduced in countries worldwide to mitigate the spread and consequences of COVID-19. Although attention has been focused on the effects of these measures on epidemiological indicators relating directly to the infection, there is increased recognition of their broader health implications. However, assessing these implications in real time is a challenge, due to the limitations of existing syndromic surveillance data and tools.

objectiveThe aim of this study is to explore the added value of mobile phone app-based symptom assessment tools as real-time health insight providers to inform public health policy makers.

methodsA comparative and descriptive analysis of the proportion of all self-reported symptoms entered by users during an assessment within the Ada app in Germany and the United Kingdom was conducted between two periods, namely before and after the implementation of "Phase One" COVID-19 measures. Additional analyses were performed to explore the association between symptom trends and seasonality, and symptom trends and weather. Differences in the proportion of unique symptoms between the periods were analyzed using a Pearson chi-square test and reported as log2 fold changes.

resultsOverall, 48,300-54,900 symptomatic users reported 140,500-170,400 symptoms during the Baseline and Measures periods in Germany. Overall, 34,200-37,400 symptomatic users in the United Kingdom reported 112,100-131,900 symptoms during the Baseline and Measures periods. The majority of symptomatic users were female (Germany: 68,600/103,200, 66.52%; United Kingdom: 51,200/71,600, 72.74%). The majority were aged 10-29 years (Germany: 68,500/100,000, 68.45%; United Kingdom: 50,900/68,800, 73.91%), and about one-quarter were aged 30-59 years (Germany: 26,200/100,000, 26.15%; United Kingdom: 14,900/68,800, 21.65%). Overall, 103 symptoms were reported either more or less frequently (with statistically significant differences) during the Measures period as compared to the Baseline period, and 34 of these were reported in both countries. The following mental health symptoms (log2 fold change, P value) were reported less often during the Measures period: inability to manage constant stress and demands at work (-1.07, P<.001), memory difficulty (-0.56, P<.001), depressed mood (-0.42, P<.001), and impaired concentration (-0.46, P<.001). Diminished sense of taste (2.26, P<.001) and hyposmia (2.20, P<.001) were reported more frequently during the Measures period. None of the 34 symptoms were found to be different between the same dates in 2019. In total, 14 of the 34 symptoms had statistically significant associations with weather variables.

conclusionsSymptom assessment apps have an important role to play in facilitating improved understanding of the implications of public health policies such as COVID-19 lockdown measures. Not only do they provide the means to complement and cross-validate hypotheses based on data collected through more traditional channels, they can also generate novel insights through a real-time syndromic surveillance system.

Indexed as

Mobile ApplicationsSentinel SurveillanceSymptom AssessmentAdolescentAdultChildCoronavirus InfectionsCOVID-19Cross-Sectional StudiesFemaleGermanyHumansMaleMiddle AgedPandemicsPneumonia, ViralCOVID-19 lockdownCOVID-19 measuresCOVID-19 symptom assessment appsdigital public healthepidemiologyhealth effects of COVID-19 measures, infoveillanceparticipatory epidemiologyparticipatory surveillancesymptom checker appssyndromic surveillance

Identifiers

PMID32997640
PMCPMC7561445

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.