Evidence map›Paper›PMID 32997567›Full record

ArticlePharmaceutical biology2020

Collagen biosynthesis stimulation and anti-melanogenesis of bambara groundnut (

Romchat Chutoprapat, Waraporn Malilas, Rattikarl Rakkaew, Sarinporn Udompong, Korawinwich Boonpisuttinant

Abstract read
In one paragraph

Article in Pharmaceutical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Rakkyo (Nutrients · 2026
    Article
  3. Article
  4. Bioinformation · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Romchat ChutoprapatDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Waraporn MalilasInstitute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
Rattikarl RakkaewInnovative Natural Products from Thai wisdom (INPTW), Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathumthani, Thailand.
Sarinporn UdompongInnovative Natural Products from Thai wisdom (INPTW), Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathumthani, Thailand.
Korawinwich BoonpisuttinantInnovative Natural Products from Thai wisdom (INPTW), Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathumthani, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextBambara groundnut (BG), originally from Africa, is widely distributed in Asian countries, especially in southern Thailand, and is used for food and functional foods. There is no report on the use of BG for ethnomedicine or cosmetics.

objectiveTo investigate collagen biosynthesis stimulation and anti-melanogenesis of the BG extracts. MATERIALS AND

methodsThe hulls (H) and seeds (S) of BG were collected from Trang province, Thailand and extracted by Soxhlet (S) and maceration (M) using ethanol, and boiled with distilled-water (B). Total phenolic (TPC) and total flavonoid (TFC) contents were quantified. The three antioxidant and tyrosinase inhibition activities were determined by DPPH, FIC and FTC; and the modified dopachrome methods, respectively. The collagen biosynthesis and the anti-melanogenesis activities were investigated by Sirius-Red and the melanin content assay.

resultsThe yields of BG extracts ranged from 1.72% to 9.06%. The BG-SS extract gave the highest TPC and TFC. The BG-HM extract showed the highest antioxidant activities (SC DISCUSSION: The biological activities of BG extracts might be from their phytochemicals, especially phenolic and flavonoid contents.

conclusionThe BG-HB and BG-HM extracts might be promising novel active sources for anti-aging and whitening cosmeceuticals.

Indexed as

AnimalsAntioxidantsCollagenDose-Response Relationship, DrugFibroblastsFlavonoidsHumansLethal Dose 50MelaninsMicePhenolsPlant ExtractsThailandVignaAntioxidantsCollagenFlavonoidsMelaninsPhenolsPlant Extractsanti-ageingAntioxidationflavonoidsnatural productphenolicswhitening

Identifiers

PMID32997567
PMCPMC7586725

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.