Evidence map›Paper›PMID 32997515›Full record

ArticleAmerican journal of physiology. Cell physiology2020

Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent.

Lien A Phung, Aurora D Foster, Mark S Miller, Dawn A Lowe, David D Thomas

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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  7. Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  8. Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lien A PhungDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Aurora D FosterDepartment of Kinesiology, University of Massachusetts, Amherst, Massachusetts.
Mark S MillerDepartment of Kinesiology, University of Massachusetts, Amherst, Massachusetts.
Dawn A LoweDepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, Minnesota.
David D ThomasDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-8822-2040
University of Minnesota · USUniversity of Massachusetts Amherst · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
Structural Dynamics of Muscle ContractionR01AR032961 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 1986 to 2018
$8.0M
Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Site-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5M
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and MalesR01AG062899 · NIA · UNIVERSITY OF MINNESOTA · PI KYBA, MICHAEL, LOWE, DAWN A · 2019 to 2023
$2.5M
Sex-specific adaptation to different resistance exercise programs in older adultsR01AG047245 · NIA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MILLER, MARK STUART · 2017 to 2021
$2.4M
Protein Oxidation, Structure, &Function in Aging MuscleR01AG026160 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 2004 to 2008
$2.2M
Molecular Biophysics of Myosin and Actin in Aged MuscleK01AG020990 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOWE, DAWN A · 2002 to 2006
$558k
Estrogenic Effects on Aged MuscleK02AG036827 · NIA · UNIVERSITY OF MINNESOTA · PI LOWE, DAWN A · 2010 to 2013
$427k
Structural Dynamics of the Myosin Super Relaxed State in Aging Muscle and Metabolic DiseaseF30AG057108 · NIA · UNIVERSITY OF MINNESOTA · PI PHUNG, LIEN AI · 2017 to 2021
$197k
Myosin structure & strength alterations in aging femalesR03AG025861 · NIA · UNIVERSITY OF MINNESOTA · PI LOWE, DAWN A · 2006 to 2007
$145k
NIAMS NIH HHS R01 AR032961NIA NIH HHS F30 AG057108NIA NIH HHS F32 AG005815NIA NIH HHS K01 AG020990NIA NIH HHS K02 AG036827NIA NIH HHS R01 AG026160NIA NIH HHS R01 AG031743NIA NIH HHS R01 AG047245NIA NIH HHS R01 AG062899NIA NIH HHS R03 AG025861NIA NIH HHS R37 AG026160NIA NIH HHS T32 AG029796NIGMS NIH HHS T32 GM008244
6 · The paper itself

Abstract

The myosin super-relaxed state (SRX) in skeletal muscle is hypothesized to play an important role in regulating muscle contractility and thermogenesis in humans but has only been examined in model organisms. Here we report the first human skeletal muscle SRX measurements, using quantitative epifluorescence microscopy of fluorescent 2'/3'-

Indexed as

AdultHumansMuscle ContractionMuscle Fibers, SkeletalMyosin Heavy ChainsProtein IsoformsQuadriceps MuscleThermogenesisYoung AdultMyosin Heavy ChainsProtein IsoformsATPaseepifluorescence microscopymantATPmyosin heavy chain (MHC)SRX

Identifiers

PMID32997515
PMCPMC7792673
OpenAlexW3091060385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.