Trial reportAlcoholism, clinical and experimental research2020
Differences in Sociodemographic and Alcohol-Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study for Alcohol Use Disorder.
Trial report in Alcoholism, clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Brain metabolite alterations related to alcohol use: a meta-analysis of proton magnetic resonance spectroscopy studies.Molecular psychiatry · 2022Pooled it
- A randomized, double-blind, placebo-controlled study of a GHSR blocker in people with alcohol use disorder.JCI insight · 2024Trial
- N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Mifepristone as a pharmacological intervention for stress-induced alcohol craving: A human laboratory study.Addiction biology · 2023Trial
- An inpatient human laboratory study assessing the safety and tolerability, pharmacokinetics, and biobehavioral effect of GET 73 when co-administered with alcohol in individuals with alcohol use disorder.Psychopharmacology · 2022Trial
- Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder.The American journal of drug and alcohol abuse · 2021Trial
- Article
- Exploring the Relationship Between Behavioral Inhibition and Approach Systems and Alcohol-Related Outcomes in People With Alcohol Use Disorder.Brain and behavior · 2025Article
- An exploratory analysis of the relationship between ultraprocessed food consumption, alcohol intake, body composition, and cardiometabolic markers in individuals with alcohol use disorder.Alcohol, clinical & experimental research · 2025Article
- Predicting treatment-seeking status for alcohol use disorder using polygenic scores and machine learning in a deeply-phenotyped sample.Drug and alcohol dependence · 2025Article
- Intranasal insulin for the treatment of alcohol use disorder: design and methodology of an alcohol interaction randomized controlled trial.Contemporary clinical trials communications · 2025Article
- Circulating Immune and Endocrine Markers in Currently Drinking and Abstinent Individuals With Alcohol Use Disorder and Controls.Addiction biology · 2025Article
- Considerations for understanding the neurobiology of pathological alcohol choice preference: Commentary on Perini, Karlsson, McIntyre, Heilig-"Neural correlates of choosing alcohol over palatable food reward in humans".Alcohol, clinical & experimental research · 2025Article
- A randomized sham-controlled trial to study the effect of transcranial direct current stimulation on craving, abstinence, and time to relapse in severe alcohol use disorder.Indian journal of psychiatry · 2025Article
- Probenecid as a pharmacotherapy for alcohol use disorder: A randomized placebo-controlled alcohol interaction trial.Alcohol, clinical & experimental research · 2024Article
- Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Evaluating the readability of online patient-facing resources for alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2024Article
- Gut microbial diversity and functional characterization in people with alcohol use disorder: A case-control study.PloS one · 2024Article
- Characteristics associated with treatment seeking for smoking cessation among heavy-drinking research participants.Frontiers in psychiatry · 2022Article
- Randomized controlled trials for alcohol use disorder during the COVID-19 pandemic.Alcohol (Fayetteville, N.Y.) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundOne of the challenges in early-stage clinical research aimed at developing novel treatments for alcohol use disorder (AUD) is that the enrolled participants are heavy drinkers, but do not seek treatment for AUD.
aimsTo compare nontreatment seekers with alcohol dependence (AD) from 4 human laboratory studies conducted at Brown University (N = 240; 65.4% male) to treatment seekers with AD from the multisite COMBINE study (N = 1,383; 69.1% male) across sociodemographic and alcohol-related clinical variables and to evaluate whether the variables that significantly differentiate the 2 samples predict the 3 main COMBINE clinical outcomes: time to relapse, percent days abstinent (PDA), and good clinical outcome.
methodsSample characteristics were assessed by parametric and nonparametric testing. Three regression models measured the association between the differing variables and the 3 main COMBINE clinical outcomes.
resultsThe nontreatment seekers, compared to the treatment seekers, were more ethnically diverse, less educated, single, and working part-time or unemployed (p's < 0.05); they met fewer DSM-IV AD criteria and had significantly lower scores on alcohol-related scales (p's < 0.05); they were less likely to have a father with alcohol problems (p < 0.0001) and had a significantly earlier age of onset and longer duration of AD (p's < 0.05); they also had significantly more total drinks, drinks per drinking day, heavy drinking days (HDD), and lower PDA in the 30 days prior to baseline (p's < 0.0001 to <0.05). Having more HDD in the 30 days prior to baseline predicted all of the 3 COMBINE clinical outcomes. All the other characteristics mentioned above that differed significantly between the 2 groups predicted at least 1 of the 3 COMBINE clinical outcomes, except for level of education, age of onset, and duration of AD.
conclusionsThe observed differences between groups should be considered in efforts across participant recruitment at different stages of the development of new treatments for AUD.
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