Evidence map›Paper›PMID 32997402›Full record

ArticleClinical and translational medicine2020

Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1-year multicenter, prospective, real-world study.

Fugui Yan, Wen Li, Wei-Jie Guan, Min Chen, Chen Qiu, Wei Tang, Xiansheng Liu, Xudong Xiang, Jing Li, Meiling Jin and 37 more

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Research progress on the pathogenesis of chest tightness variant asthma characterized by chest tightness.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 16 institutions in 1 country.

Fugui YanKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Wen LiKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Wei-Jie GuanDepartment of Respiratory Medicine, State Key Laboratory of Respiratory Disease, Guangzhou Institute for Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Min ChenDepartment of Respiratory Medicine, Affiliated Hospital, Guangdong Medical University, Zhanjiang, China.
Chen QiuDepartment of Respiratory Medicine, Shenzhen People's Hospital, Shenzhen, China.
Wei TangDepartment of Respiratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xiansheng LiuDepartment of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xudong XiangDepartment of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
Jing LiDepartment of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, The First Hospital, Guangzhou Medical University, Guangzhou, China.
Meiling JinDepartment of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuanrong DaiDepartment of Pulmonary Medicine, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ping ChenDepartment of Pulmonary Medicine, General Hospital of Northern Theater Command of the Chinese People's Liberation Army, Shenyang, China.
Xiaohong WuDepartment of Pulmonary Medicine, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhongmin QiuDepartment of Pulmonary Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Liang DongDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, China.
Limin ZhaoDepartment of Pulmonary Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoping LinDepartment of Pulmonary Medicine, Second Affiliated Hospital of Fujian Medical University, Fujian, China.
Changgui WuDepartment of Respiratory Disease, Xijing Hospital, The Fourth Military Medical University, Xian, China.
Bin WuDepartment of Respiratory Medicine, Affiliated Hospital, Guangdong Medical University, Zhanjiang, China.
Yalian YuanDepartment of Respiratory Medicine, Affiliated Hospital, Guangdong Medical University, Zhanjiang, China.
Fei ShiDepartment of Respiratory Medicine, Shenzhen People's Hospital, Shenzhen, China.
Ting ZhangDepartment of Respiratory Medicine, Shenzhen People's Hospital, Shenzhen, China.
Jun ZhouDepartment of Respiratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Min XieDepartment of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaoyu FangDepartment of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hongliang ZhangDepartment of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
Bing XiaoDepartment of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
Mo XianDepartment of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, The First Hospital, Guangzhou Medical University, Guangzhou, China.
Jian WangDepartment of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhangwei QiuDepartment of Pulmonary Medicine, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jie LinDepartment of Pulmonary Medicine, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Bingbing JiDepartment of Pulmonary Medicine, General Hospital of Northern Theater Command of the Chinese People's Liberation Army, Shenyang, China.
Yong ZhouDepartment of Pulmonary Medicine, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yu LiDepartment of Pulmonary Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Chunhong LiuDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, China.
Yiping ChenDepartment of Pulmonary Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Yiming ZengDepartment of Pulmonary Medicine, Second Affiliated Hospital of Fujian Medical University, Fujian, China.ORCID https://orcid.org/0000-0001-5635-3006
Lingli LiuDepartment of Respiratory Disease, Xijing Hospital, The Fourth Military Medical University, Xian, China.
Wen HuaKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Huaqiong HuangKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Jiesen ZhouKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yue HuKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Luanqing CheKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Songmin YingKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Zhihua ChenKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Nanshan ZhongDepartment of Respiratory Medicine, State Key Laboratory of Respiratory Disease, Guangzhou Institute for Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Huahao ShenKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0001-9546-9351
Second Affiliated Hospital of Zhejiang University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNCentral South University · CNGuangdong Medical College · CNRuijin Hospital · CNShenZhen People’s Hospital · CNTongji Hospital · CNTongji University · CNFudan University · CNFujian Medical University · CNGeneral Hospital of Shenyang Military Region · CNQilu Hospital of Shandong University · CNSir Run Run Shaw Hospital · CNWenzhou Medical University · CNXijing Hospital · CNZhengzhou University · CN

Funding

Precision Medicine Research of the National Key Research and Development Plan of China 2016YFC0905800Zhejiang Medical and Health Science and Technology program from Health Commission of Zhejiang Province WKJ2014-ZJ-01412
6 · The paper itself

Abstract

backgroundAsthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear.

objectiveThe response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long-acting beta-agonists was explored in a 52-week multicenter, prospective, real-world study.

resultsAfter 52 weeks of treatment with therapy regimens used for CA, the mean 5-point Asthma Control Questionnaire (ACQ-5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447-0.900, P<.001).The mean asthma quality-of-life questionnaire (AQLQ) score increased from 5.77 (first administration) to 6.20 (52 weeks, mean increase: 0.441, 95% CI 0.258-0.625, P<.001). Furthermore, at week 52, FVC, FEV

conclusionIn conclusion, patients with CTVA had a good therapeutic response to the guideline-recommended routine treatment (containing inhaled corticosteroids). The association between the treatment response and the severity of CTVA suggested that CTVA patients with higher ACQ-5 scores had better therapeutic effects.

Indexed as

chest tightness variant asthmainhaled corticosteroidslong-acting beta-agonistsreal-world study

Identifiers

PMID32997402
PMCPMC7503098
OpenAlexW3087026613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.