ArticleEuropean journal of neurology2021
Muscle involvement in SARS-CoV-2 infection.
Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- New-onset dermatomyositis following SARS-CoV-2 infection and vaccination: a case-based review.Rheumatology international · 2022Pooled it
- Functional and Psychological Changes after Exercise Training in Post-COVID-19 Patients Discharged from the Hospital: A PRISMA-Compliant Systematic Review.International journal of environmental research and public health · 2022Pooled it
- The use of statins was associated with reduced COVID-19 mortality: a systematic review and meta-analysis.Annals of medicine · 2021 · on this mapPooled it
- Early Postural Instability with History of COVID-19 Influence Related to Diabetes: An Exploratory Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Assessment of muscle wasting in intensive care unit patients with and without COVID-19 using ultrasound imaging and bioimpedance analysis.BMC anesthesiology · 2026Article
- Convergent innate immune and regulated cell-death pathways in selected myopathies.Frontiers in immunology · 2026Review
- Abnormal Serum Albumin, Alanine Aminotransferase, and Blood Urea Nitrogen are Associated with Higher Risks for Mechanical Ventilation and In-Hospital Mortality in COVID-19 Positive US Veterans.Biomarker insights · 2026Article
- Zika virus infection disturbs development of human muscle progenitor cells.Frontiers in cellular and infection microbiology · 2025Article
- Observational
- Comparison of clinical characteristics and disease burden of febrile seizures in children with and without COVID-19.BMC pediatrics · 2024Article
- Muscle strength/intensive care unit acquired weakness in COVID-19 and non-COVID-19 patients.Nursing in critical care · 2023Article
- Neurological Manifestations of Coronavirus Disease 2019 in Hospitalized Patients: A Lebanese Cohort Study.Cureus · 2023Article
- Clinical features of febrile seizures in children with COVID-19: an observational study from a tertiary care hospital in China.Frontiers in pediatrics · 2023Article
- Interleukin6 prediction of mortality in critically ill COVID19 patients: A prospective observational cohort study.PloS one · 2023Observational
- Skeletal Muscle Manifestations and Creatine Kinase in COVID-19.The Neurohospitalist · 2022Article
- Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology.European journal of neurology · 2022Article
- Skeletal Muscle and COVID-19: The Potential Involvement of Bioactive Sphingolipids.Biomedicines · 2022Review
- Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19.Journal of cachexia, sarcopenia and muscle · 2022Review
- Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections.Frontiers in neurology · 2022Review
- Clinical Characteristics and Mechanisms of Musculoskeletal Pain in Long COVID.Journal of pain research · 2022Review
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSince the outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, several reports indicated neurological involvement in COVID-19 disease. Muscle involvement has also been reported as evidenced by creatine kinase (CK) elevations and reports of myalgia.
methodsCreatine kinase, markers of inflammation, pre-existing diseases and statin use were extracted from records of Austrian hospitalised COVID-19 patients. Disease severity was classified as severe in case of intensive care unit (ICU) admission or mortality. COVID-19 patients were additionally compared to an historical group of hospitalised influenza patients.
resultsThree hundred fifty-one patients with SARS-CoV-2 and 258 with influenza were included in the final analysis. CK was elevated in 27% of COVID-19 and in 28% of influenza patients. CK was higher in severe COVID-19 as were markers of inflammation. CK correlated significantly with inflammation markers, which had an independent impact on CK when adjusted for demographic variables and disease severity. Compared to influenza patients, COVID-19 patients were older, more frequently male, had more comorbidities, and more frequently had a severe disease course. Nevertheless, influenza patients had higher baseline CK than COVID-19, and 35.7% of intensive care unit (ICU)-admitted patients had CK levels >1,000 U/L compared to only 4.7% of ICU-admitted COVID-19 patients.
conclusionsHyperCKemia occurs in a similar frequency in COVID-19 and influenza infection. CK levels were lower in COVID-19 than in influenza in mild and severe disease. CK levels strongly correlate with disease severity and markers of inflammation. To date, it remains unclear whether hyperCKemia is due to a virus-triggered inflammatory response or direct muscle toxicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.