Trial reportWorld journal of urology2021
A prospective multicenter randomized comparison between Holmium Laser Enucleation of the Prostate (HoLEP) and Thulium Laser Enucleation of the Prostate (ThuLEP).
Trial report in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07456345 (Evaluation of the Impact of Preoperative Pelvic Floor Exercise on Incontinence After Laser Enucleation of the Prostate), which is not on this map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Impact of Preoperative Pelvic Floor Exercise on Incontinence After Laser Enucleation of the Prostate: a Prospective Feasibility Study.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- "Defining the Drip: A Systematic Review of Incontinence Definitions and Predictors Following HoLEP".Current urology reports · 2025Pooled it
- The safety and efficacy of five surgical treatments in prostate enucleation: a network meta-analysis.BMC urology · 2024Pooled it
- Advances in lasers for the minimally invasive treatment of upper and lower urinary tract conditions: a systematic review.World journal of urology · 2023Pooled it
- Incidence and risk factors for postoperative urinary incontinence after various prostate enucleation procedures: systemic review and meta-analysis of PubMed literature from 2000 to 2021.World journal of urology · 2022Pooled it
- Prospective single-center study comparing RealPulseWorld journal of urology · 2026Trial
- Impact of laser power settings on sexual and urinary outcomes in holmium laser enucleation of the prostate: a multicenter randomized controlled trial.Lasers in medical science · 2025Trial
- Comparative Effectiveness and Safety of Thulium Laser Enucleation and Holmium Laser Enucleation for BPH: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Holmium laser enucleation of the prostate as salvage therapy for benign prostatic obstruction after multiple prior surgical interventions.World journal of urology · 2026Article
- HoLEP versus ThuFLEP: perioperative and functional outcomes in prostate enucleation.Lasers in medical science · 2026Article
- A paradigm shift in urology training: Laser endoscopic enucleation of the prostate may be easier than transurethral resection of the prostate in the learning curve of urology residents.Prostate international · 2026Article
- Safety and efficacy of thulium laser enucleation of the prostate within two weeks following transperineal biopsy.Lasers in medical science · 2026Article
- P.I. nomogram: an exploratory imaging-derived model for predicting early urinary incontinence following ThuLEP.World journal of urology · 2026Article
- Switching lasers: assessing the learning curves of surgeons with different levels of surgical experience when switching from HoLEP to pulsed Thulium YAG lasers for ThuLEP.Frontiers in surgery · 2026Article
- Thulium fibre laser endoscopic enucleation of the prostate (THUFLEP) learning curve assessment: A retrospective analysis of the experience of a single surgeon.BJUI compass · 2025Article
- Letter to editor: Efficacy and safety in enucleation of the prostate with thulium fiber laser (TFL) using a 365 μm fiber-a retrospective study in a real-world, risk-diverse population.World journal of urology · 2025Article
- Multicenter comparative analysis of preoperative and postoperative outcomes after holmium laser enucleation of the prostate based on the prostate volume.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025Article
- Holmium: YAG laser enucleation of the prostate using the new cyber Ho generator with magneto technology: does it provide any advantages compared to thulium: YAG prostate enucleation?World journal of urology · 2025Article
- Smooth muscle contractility of laser-enucleated prostate tissues and impacts of preoperative αScientific reports · 2025Article
- Three surgical techniques using different energy sources for anatomical endoscopic enucleation of the prostate.Frontiers in surgery · 2025Review
- Feasibility, safety and efficacy of using low-power thulium: YAG laser enucleation of prostate compared to HoLEP in developing country.Central European journal of urology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare intra and perioperative parameters between HoLEP and ThuLEP in the treatment of benign prostatic hyperplasia and to evaluate clinical and functional outcomes of the two procedures with a 12-month follow-up.
methodsA prospective randomized study was performed on 236 consecutive patients who underwent ThuLEP (n = 115), or HoLEP (n = 121) in three different centers. Intra and perioperative parameters were analyzed: operative time, enucleated tissue weight, irrigation volume, blood loss, catheterization time, hospital stay and complications. Patients were evaluated preoperatively and 3 and 12 months postoperatively with the international prostate symptom score (IPSS), the quality of life (QoL) score, post-void residual volume (PVR), PSA and maximum flow rate (Q
resultsPreoperative variables in each study arm did not show any significant difference. Compared to HoLEP, ThuLEP showed similar operative time (63.69 vs 71.66 min, p = 0.245), enucleated tissue weight (48.84 vs 51.13 g, p = 0.321), catheterization time (1.9 vs 2.0 days, p = 0.450) and hospital stay (2.2 vs 2.8 days, p = 0.216), but resulted in less haemoglobin decrease (0.45 vs 2.77 g/dL, p = 0.005). HoLEP presented a significantly higher number of patients with postoperative acute urinary retention and stress incontinence. No significant differences were found in PSA, Q
conclusionThuLEP and HoLEP both relieved lower urinary tract symptoms equally, with high efficacy and safety. ThuLEP detemined reduced blood loss and early postoperative complications. Catheterization time, enucleated tissue, hospital stay, operative time and follow-up parameters did not show any significant difference.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.