ArticleJournal of applied oral science : revista FOB2020
Increase in serum and salivary neutrophil gelatinase-associated lipocalin levels with increased periodontal inflammation.
Article in Journal of applied oral science : revista FOB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the implications of lipocalin-2 expression in periodontal disease.Evidence-based dentistry · 2025Pooled it
- Article
- Article
- Pro-Inflammatory and Anti-Inflammatory Interleukins in Periodontitis: Molecular Roles, Immune Crosstalk, and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Serum cytokines in periodontal diseases.Periodontology 2000 · 2025Review
- Lipocalin-2 as a fundamental protein in type 2 diabetes and periodontitis in mice.Journal of periodontology · 2025Article
- Meteorin-like levels of oral fluids in periodontal health and diseases: a comparative cross-sectional study.Clinical oral investigations · 2025Article
- Periodontal disease: A systemic condition.Periodontology 2000 · 2024Review
- Diagnostic Potential of Salivary Interleukin-1International journal of dentistry · 2024Article
- Article
- Periodontal Inflamed Surface Area (PISA) associates with composites of salivary cytokines.PloS one · 2023Article
- Increase in the level of oral neutrophils with gingival inflammation - A population survey.The Saudi dental journal · 2022Article
- Effect of polycaprolactone nanofibers loaded with oxytetracycline hydrochloride and zinc oxide as an adjunct to SRP on GCF lipocalin-2 levels in periodontitis patients: A clinical and laboratory study.Journal of advanced periodontology & implant dentistry · 2022Article
- In Vitro Compression Model for Orthodontic Tooth Movement Modulates Human Periodontal Ligament Fibroblast Proliferation, Apoptosis and Cell Cycle.Biomolecules · 2021Article
- Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination.Journal of clinical medicine · 2021Article
- Periodontal Inflammation and Systemic Diseases: An Overview.Frontiers in physiology · 2021Review
- Impact of Cellular Senescence on LCN2 Expression in Salivary Gland Epithelial Cells and Oral Keratinocytes.BioFactors (Oxford, England)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to determine serum and salivary levels of neutrophil gelatinase-associated lipocalin (NGAL) and evaluate NGAL correlation with key anti-interleukin 10 (IL-10) and pro-inflammatory (IL-1β) cytokines in different severities of periodontal diseases. We also calculated the systemic inflammation using the periodontal inflamed surface area (PISA) to evaluate its correlation with NGAL in the study groups. METHODOLOGY: Eighty systemically healthy and non-smoking individuals were separated into four groups of 20: clinically healthy (Group 1), gingivitis (Group 2), stage I generalized periodontitis (Group 3, Grade A), and stage III generalized periodontitis (Group 4, Grade A). Sociodemographic characteristics and periodontal parameters were recorded, and PISA was calculated. The serum and salivary levels of interleukin (IL)-1β, IL-10, and NGAL were determined using the enzyme-linked immunosorbent assay (ELISA).
resultsWe observed a significant increase in serum and salivary NGAL levels from healthy to periodontitis groups (p=0.000). Group 2 presented significantly higher serum and salivary IL-10 levels and salivary IL-1β levels than Group 3 (p=0.000). Serum and salivary parameters (IL-1β, IL-10, and NGAL levels) were strongly positively correlated to periodontal parameters and PISA values (p=0.000). Groups 2 and 3 showed overlapping PISA values.
conclusionThe overlapping PISA values found in Groups 2 and 3 suggest that gingivitis might progress to a systemic inflammatory burden somewhat comparable to stage I periodontitis. This finding is supported by the higher serum and salivary cytokines/mediators levels in the gingivitis group than in stage I periodontitis group. Serum and salivary NGAL levels increased proportionally to disease severity and PISA. NGAL seems to play a role in the pathogenesis of periodontal disease, within the limitation of our study.
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