ArticleRevista da Sociedade Brasileira de Medicina Tropical2020
Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosis: average turnaround time.
Article in Revista da Sociedade Brasileira de Medicina Tropical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Application of Metagenomic Next-Generation Sequencing inFrontiers in medicine · 2022Pooled it
- Metagenomic next-generation sequencing for tuberculosis diagnosis: enhanced performance and cost-effectiveness.Microbiology spectrum · 2026Observational
- Tuberculosis Diagnostic Methods: Clinical Applicability, Implementation Challenges, and Integrated Testing Strategies.Pathogens (Basel, Switzerland) · 2026Review
- Analysis of the onset characteristics and diagnosis of 217 cases of renal tuberculosis.European journal of medical research · 2025Article
- Diagnostic performance of Ziehl-Neelsen staining and Auramine-Rhodamine staining techniques in the detection of pulmonary and extrapulmonary tuberculosis.Revista peruana de medicina experimental y salud publica · 2025Article
- Conventional DNA Extraction Followed by Real-Time PCR Had Higher Sensitivity for Detection of Mycobacterium Tuberculosis in Clinical Samples Compared to Standard Methods.The American journal of tropical medicine and hygiene · 2025Article
- Image database with slides prepared by the Ziehl-Neelsen method for training automated detection and counting systems for tuberculosis bacilli.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Emergence ofFrontiers in public health · 2025Review
- Cytochemical analysis of cerebrospinal fluid in tuberculous meningitis versus other etiologies.PloS one · 2025Article
- Early cost-effectiveness analysis of a novel rapid diagnostic test for tuberculosis in rural Philippine settings.PLOS global public health · 2025Article
- Tuberculosis Diagnosis: Current, Ongoing, and Future Approaches.Diseases (Basel, Switzerland) · 2024Review
- Pulmonary Tuberculosis Diagnosis Using an Intelligent Microscopy Scanner and Image Recognition Model for Improved Acid-Fast Bacilli Detection in Smears.Microorganisms · 2024Article
- Case report: Difficult diagnosis ofFrontiers in oncology · 2024Article
- Diagnostic performance of the Cobas MTB and Logix Smart MTB for diagnosing pulmonary and extrapulmonary tuberculosis: a cross-sectional study of diagnostic tests.Therapeutic advances in infectious diseaseArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRapid and accurate tuberculosis detection is critical for improving patient diagnosis and decreasing tuberculosis transmission. Molecular assays can significantly increase laboratory costs; therefore, the average time and economic impact should be evaluated before implementing a new technology. The aim of this study was to evaluate the cost and average turnaround time of smear microscopy and Xpert assay at a university hospital.
methodsThe turnaround time and cost of the laboratory diagnosis of tuberculosis were calculated based on the mean cost and activity based costing (ABC).
resultsThe average turnaround time for smear microscopy was 16.6 hours while that for Xpert was 24.1 hours. The Xpert had a mean cost of USD 17.37 with an ABC of USD 10.86, while smear microscopy had a mean cost of USD 13.31 with an ABC of USD 6.01. The sensitivity of smear microscopy was 42.9% and its specificity was 99.1%, while the Xpert assay had a sensitivity of 100% and a specificity of 96.7%.
conclusionsThe Xpert assay has high accuracy; however, the turnaround time and cost of smear microscopy were lower than those of Xpert.
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