Evidence map›Paper›PMID 32996723›Full record

ArticleBirth defects research2021

Assessing the relationship between neonatal abstinence syndrome and birth defects in Delaware.

Khaleel S Hussaini, Dana Drummond, Louis E Bartoshesky, Amy Acheson, Kathleen Stomieroski, David A Paul, Russell S Kirby

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth defects research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Khaleel S HussainiField Support Branch, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-7635-2622
Dana DrummondDrug Overdose Surveillance Epidemiologist, Division of Prevention and Community Health, Washington State Department of Health, Tumwater, Washington, USA.
Louis E BartosheskyPediatrics, ChristianaCare™, Newark, Delaware, USA.
Amy AchesonCenter for Women's, Infants' and Children's Health Research, ChristianaCare™, Newark, Delaware, USA.
Kathleen StomieroskiCenter for Women's, Infants' and Children's Health Research, ChristianaCare™, Newark, Delaware, USA.
David A PaulPediatrics, ChristianaCare™, Newark, Delaware, USA.
Russell S KirbyDistinguished Professor and Marrell Endowed Chair, Birth Defects Surveillance ProgramCollege of Public Health, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-3489-401X
Christiana Care Health System · USCenters for Disease Control and Prevention · USUniversity of South Florida · USWashington State Department of Health · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundNeonatal abstinence syndrome (NAS) is a withdrawal syndrome in newborns and is frequently caused by maternal opioid use during pregnancy. Our study examines whether NAS is associated with birth defects in Delaware.

methodsWe conducted a retrospective analysis of linked Delaware birth certificate data (BCD), hospital discharge data (HDD), and birth defects registry (BDR) data to examine the association between NAS and birth defects for all hospital births to Delaware residents from 2010 to 2017. Birth defects data were abstracted from medical records from Delaware's BDR. We used International Classification of Diseases Ninth and Tenth Revision Clinical Modification (ICD-9-CM/ICD-10-CM) 779.5 and P96.1 codes to determine NAS using HDD and excluded iatrogenic cases of NAS. We estimated crude and adjusted odds ratio with 95% confidence intervals (CIs).

resultsDuring 2010-2017, there were 2,784 cases of birth defects and 1,651 cases of NAS in Delaware. Among infants with a diagnosis of NAS, 56 also had a birth defect (3.4%), similar to 2,728 birth defects among 79,636 infants without a diagnosis of NAS (3.4%). We found no statistically significant association between an NAS diagnosis and birth defects (adjusted odds ratios = 1.0; 95% CI: 0.8-1.3).

conclusionsOur multiyear state-wide study using linked BCD, HDD, and BDR data for Delaware did not show a statistically significant association between infants diagnosed with NAS and birth defects, overall.

Indexed as

Neonatal Abstinence SyndromeDelawareFemaleHumansInfant, NewbornInternational Classification of DiseasesPregnancyRegistriesRetrospective Studiesbirth certificate databirth defectsbirth defects registrydata linkagehospital discharge dataneonatal abstinence syndromeopioid use disorder

Identifiers

PMID32996723
PMCPMC10947796
OpenAlexW3090000907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.