Evidence map›Paper›PMID 32996603›Full record

ReviewVox sanguinis2021

Pharmacogenomics with red cells: a model to study protein variants of drug transporter genes.

Willy Albert Flegel, Kshitij Srivastava, Tristan Michael Sissung, Barry Ronald Goldspiel, William Douglas Figg

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vox sanguinis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Willy Albert FlegelDepartment of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-1631-7198
Kshitij SrivastavaDepartment of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Tristan Michael SissungClinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Barry Ronald GoldspielClinical Trials Operations and Informatics Branch, Cancer Therapy Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
William Douglas FiggClinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USNational Institutes of Health Clinical Center · US

Funding

Clinical PharmacogeneticsZIABC010627 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FIGG, WILLIAM DOUGLAS · 2009 to 2025
$13.9M
Clinical PharmacologyZ01BC010627 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FIGG, WILLIAM DOUGLAS · 2004 to 2008
$938k
Laboratory Services Section, Department of Transfusion Medicine Core ReportZICCL002128 · CLC · CLINICAL CENTER · PI FLEGEL, WILLY · 2020 to 2025
$0k
CLC NIH HHS Z99 CL999999Intramural NIH HHS Z01 BC010627Intramural NIH HHS Z99 CL999999Intramural NIH HHS ZIA BC010627Intramural NIH HHS ZIC CL002128
6 · The paper itself

Abstract

The PharmacoScan pharmacogenomics platform screens for variation in genes that affect drug absorption, distribution, metabolism, elimination, immune adverse reactions and targets. Among the 1,191 genes tested on the platform, 12 genes are expressed in the red cell membrane: ABCC1, ABCC4, ABCC5, ABCG2, CFTR, SLC16A1, SLC19A1, SLC29A1, ATP7A, CYP4F3, EPHX1 and FLOT1. These genes represent 5 ATP-binding cassette proteins, 3 solute carrier proteins, 1 ATP transport protein and 3 genes associated with drug metabolism and adverse drug reactions. Only ABCG2 and SLC29A1 encode blood group systems, JR and AUG, respectively. We propose red cells as an ex vivo model system to study the effect of heritable variants in genes encoding the transport proteins on the pharmacokinetics of drugs. Altered pharmacodynamics in red cells could also cause adverse reactions, such as haemolysis, hitherto unexplained by other mechanisms.

Indexed as

PharmacogeneticsPolymorphism, GeneticATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2Blood Group AntigensCopper-Transporting ATPasesCystic Fibrosis Transmembrane Conductance RegulatorCytochrome P450 Family 4Epoxide HydrolasesEquilibrative Nucleoside Transporter 1ErythrocytesHumansMembrane ProteinsMembrane Transport ProteinsMonocarboxylate Transport Protein 1ABCC4 protein, humanABCC5 protein, humanABCG2 protein, humanATP7A protein, humanATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2Blood Group AntigensCFTR protein, humanCopper-Transporting ATPasesCYP4F3 protein, humanCystic Fibrosis Transmembrane Conductance RegulatorCytochrome P450 Family 4EPHX1 protein, humanEpoxide HydrolasesEquilibrative Nucleoside Transporter 1flotillinsMembrane ProteinsMembrane Transport ProteinsMonocarboxylate Transport Protein 1Monocarboxylic Acid Transportersmultidrug resistance-associated protein 1Neoplasm ProteinsReduced Folate Carrier ProteinSLC19A1 protein, humanSLC29A1 protein, humanSymportersDMETdrug transporterserythrocytespharmacogeneticspharmacogenomicsPharmacoScan

Identifiers

PMID32996603
PMCPMC9108996
OpenAlexW3090011579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.