ArticleThe American journal of tropical medicine and hygiene2020
Experience of a Tertiary Hospital in Singapore with Management of a Dual Outbreak of COVID-19 and Dengue.
Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Measuring real-time disease transmissibility with temperature-dependent generation intervals.PLoS computational biology · 2026Article
- Risk of dengue following prior SARS-CoV-2 infection: a population-based cohort study.The Lancet regional health. Western Pacific · 2025Article
- Lessons and concerns about the SARS-CoV-2/DENV co-infection.BMC infectious diseases · 2025Article
- Acute and Postacute Health Care Utilization and Costs After Dengue Infection: A Population-Based Cohort Study.Open forum infectious diseases · 2025Article
- Long-term Sequelae Following Dengue Infection vs SARS-CoV-2 Infection in a Pediatric Population: A Retrospective Cohort Study.Open forum infectious diseases · 2025Article
- Development of a multi-epitope vaccine candidate to combat SARS-CoV-2 and dengue virus co-infection through an immunoinformatic approach.Frontiers in immunology · 2025Article
- Effects of Recent Prior Dengue Infection on Risk and Severity of Subsequent SARS-CoV-2 Infection: A Retrospective Cohort Study.Open forum infectious diseases · 2024Article
- Clinical Features of COVID-19, Dengue, and Influenza among Adults Presenting to Emergency Departments and Urgent Care Clinics-Puerto Rico, 2012-2021.The American journal of tropical medicine and hygiene · 2023Article
- SARS-CoV-2 and dengue virus co-infection: Epidemiology, pathogenesis, diagnosis, treatment, and management.Reviews in medical virology · 2023Review
- Singapore's Dengue Outbreak Amidst the COVID-19 Pandemic: Challenges, Responses, and Lessons.Infection and drug resistance · 2023Article
- Dengue and COVID-19: Managing Undifferentiated Febrile Illness during a "Twindemic".Tropical medicine and infectious disease · 2022Article
- Coinfection With SARS-CoV-2 and Dengue Virus: A Case Report Highlighting Diagnostic Challenges.Frontiers in tropical diseases · 2022Article
- The Usefulness of Peripheral Blood Cell Counts to Distinguish COVID-19 from Dengue during Acute Infection.Tropical medicine and infectious disease · 2022Article
- Detection of SARS-CoV-2 antibodies in febrile patients from an endemic region of dengue and chikungunya in Peru.PloS one · 2022Article
- Coinfection and cross-reaction of dengue and COVID-19: a case series analysis.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Diagnosis of Dengue in a returning traveler from Pakistan suspected of COVID-19, California, USA.Diagnostic microbiology and infectious disease · 2021Article
- One Year on: An Overview of Singapore's Response to COVID-19-What We Did, How We Fared, How We Can Move Forward.International journal of environmental research and public health · 2021Review
- Pandemic-associated mobility restrictions could cause increases in dengue virus transmission.PLoS neglected tropical diseases · 2021Article
- The Pandemic Experience in Southeast Asia: Interface Between SARS-CoV-2, Malaria, and Dengue.Frontiers in tropical diseases · 2021Article
- The Complexity of Co-Infections in the Era of COVID-19.SN comprehensive clinical medicine · 2021Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the COVID-19 pandemic, distinguishing dengue from cases of COVID-19 in endemic areas can be difficult. In a tertiary hospital contending with COVID-19 during a dengue epidemic, a triage strategy of routine COVID-19 testing for febrile patients with viral prodromes was used. All febrile patients with viral prodromes and no epidemiologic risk for COVID-19 were first admitted to a designated ward for COVID-19 testing, where enhanced personal protective equipment was used by healthcare workers until COVID-19 was ruled out. From January to May 2020, 11,086 admissions were screened for COVID-19; 868 cases of COVID-19 were diagnosed in our institution, along with 380 cases of dengue. Only 8.5% (943/11,086) of suspected COVID-19 cases were concurrently tested for dengue serology due to a compatible overlapping clinical syndrome, and dengue was established as an alternative diagnosis in 2% (207/10,218) of suspected COVID-19 cases that tested negative. There were eight COVID-19 cases with likely false-positive dengue serology and one probable COVID-19/dengue coinfection. From April to May 2020, 251 admissions presenting as viral prodromes with no respiratory symptoms were screened; of those, 15 cases had COVID-19, and 2/15 had false-positive dengue IgM. Epidemiology investigations showed no healthcare-associated transmission. In a dengue epidemic season coinciding with a COVID-19 pandemic, dengue was established as an alternative diagnosis in a minority of COVID-19 suspects, likely due to early availability of basic diagnostics. Routine screening of patients with viral prodromes during a dual outbreak of COVID-19 and dengue enabled containment of COVID-19 cases masquerading as dengue with false-positive IgM.
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