Evidence map›Paper›PMID 32996043›Full record

ArticleInflammopharmacology2021

Euterpe oleracea Mart. (Açaí) attenuates experimental colitis in rats: involvement of TLR4/COX-2/NF-ĸB.

Carlos Eduardo da Silva Monteiro, Humberto Barbosa da Costa Filho, Francisca Géssica Oliveira Silva, Maria de Fathima Felipe de Souza, Johnatan Alisson Oliveira Sousa, Álvaro Xavier Franco, Ângela Castro Resende, Roberto Soares de Moura, Marcellus Henrique Loiola de Souza, Pedro Marcos Gomes Soares and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Açaí (Nutrients · 2023
    Review
  10. Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Carlos Eduardo da Silva MonteiroLEFFAG-Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Humberto Barbosa da Costa FilhoLEFFAG-Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Francisca Géssica Oliveira SilvaLEFFAG-Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Maria de Fathima Felipe de SouzaLEFFAG-Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Johnatan Alisson Oliveira SousaLEFFAG-Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Álvaro Xavier FrancoLEFFAG-Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Ângela Castro ResendeDepartment of Pharmacology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Roberto Soares de MouraDepartment of Pharmacology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marcellus Henrique Loiola de SouzaLEFFAG-Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Pedro Marcos Gomes SoaresLEFFAG-Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
André Luiz Dos Reis BarbosaLAFFEX-Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Av. São Sebastião 2819, Parnaíba, PI, 64202-020, Brazil. andreluiz@ufpi.edu.br.ORCID https://orcid.org/0000-0002-6452-9160
Universidade Federal do Ceará · BRUniversidade do Estado do Rio de Janeiro · BRUniversidade Federal do Piauí · BR

Funding

CNPq 301981/2016-7
6 · The paper itself

Abstract

Euterpe oleracea Mart., commonly known as açaí, has been demonstrated to exhibit significantly antioxidant and inflammatory activities in experimental models. These effects of the hydroalcoholic extract from the açaí seed (ASE) were investigated in TNBS-induced (2,4,6-trinitrobenzenesulfonic acid) acute colitis model in rats. Wistar rats (180-220 g) were orally pretreated with saline (0.3 mL), ASE (10, 30 and 100 mg/kg) and dexamethasone (control group, 1 mg/kg) once daily for 3 days starting before TNBS instillation. On day 3 after TNBS, the animals were euthanized, the portion of distal colon was collected and washed with 0.9% saline for macroscopy and histological evaluation, glutathione (GSH) and malonyldialdehyde (MDA) levels, myeloperoxidase (MPO) and catalase (CAT) activity, nitrate and nitrite (NO

Indexed as

AnimalsAntioxidantsColitisCyclooxygenase 2Disease Models, AnimalDose-Response Relationship, DrugEuterpeInflammationMaleNF-kappa BOxidative StressPlant ExtractsRatsRats, WistarToll-Like Receptor 4Trinitrobenzenesulfonic AcidAntioxidantsCyclooxygenase 2NF-kappa BPlant ExtractsTlr4 protein, ratToll-Like Receptor 4Trinitrobenzenesulfonic AcidAçaí seed extractEpithelial barrier and epithelial barrierInflammationTNBS-induced colitis

Identifiers

PMID32996043
OpenAlexW3090699531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.