ArticleClinical oral investigations2021
Combined effect of casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate on the prevention of enamel demineralization and dental caries: an in vitro study.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Do universal adhesives applied with different modes affect remineralized enamel surfaces? A SEM study.Odontology · 2026Article
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- A Systematic Review on a Variety of Alternate Fluoride Options Effective in Preventing Dental Caries.Journal of pharmacy & bioallied sciences · 2026Article
- Polyphosphate-based strategies in enamel remineralization: mechanisms, evidence, and clinical potential.Frontiers in oral health · 2026Review
- Evaluation of the Effect of Different Universal Adhesives on Remineralized Enamel by Shear Bond Strength and Fe-SEM/EDX Analysis.Journal of functional biomaterials · 2025Article
- Improving Enamel Acid Resistance by an Intraoral Fluoride-Release Device Incorporating Cationic Hydroxy Cellulose Gel Using 3D Printer Molding.Materials (Basel, Switzerland) · 2024Article
- In Vitro Models Used in Cariology Mineralisation Research-A Review of the Literature.Dentistry journal · 2024Review
- The Effects of Khat Chewing among Djiboutians: Dental Chemical Studies, Gingival Histopathological Analyses and Bioinformatics Approaches.Bioengineering (Basel, Switzerland) · 2024Article
- Engineered Biomaterials Trigger Remineralization and Antimicrobial Effects for Dental Caries Restoration.Molecules (Basel, Switzerland) · 2023Review
- Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023Article
- Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate.Antibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo evaluate the effect of treatment with fluoridated toothpaste supplemented with a combination of sodium trimetaphosphate (TMP) and casein phosphopeptide-amorphous calcium phosphate (MI Paste Plus
methodsBovine enamel blocks selected by initial surface hardness (SHi) were randomly allocated into six groups (n = 12), according to the test toothpastes: (1) without F-TMP-MI Paste Plus
resultsThe 1100F-TMP-MI Paste Plus group showed better results for SHR, ΔKHN, and PLM (p < 0.001). The F concentration was similar among all groups (p > 0.001). The 1100F-TMP-MI Paste Plus group showed the highest concentration of Ca and P in the enamel (p < 0.001).
conclusionThe application of 1100F-TMP-MI Paste Plus promoted a higher inhibitory effect against enamel demineralization. CLINICAL SIGNIFICANCE: The combination of treatments with F, TMP, and MI Paste Plus
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.