SynthesisNeuroradiology2021
Understanding brain resilience in superagers: a systematic review.
Synthesis in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What characterizes the exceptional cognition of superagers? A systematic review of multidomain biomarkers of successful cognitive aging.The Gerontologist · 2026Pooled it
- A Comparative Study of Aging and Cortical Folding in Chimpanzees and Olive Baboons.American journal of primatology · 2026Article
- Cohort profile: the Resilient Minds national study of mental health and cognitive resilience in community dwelling adults aged 18 to 93.Frontiers in digital health · 2026Article
- Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology.Alzheimer's research & therapy · 2025Review
- Preserved brain youthfulness: longitudinal evidence of slower brain aging in superagers.GeroScience · 2025Article
- Functional Connectome of Superagers Reveals Early Markers of Resilience and Vulnerability to Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Super Movers: Epidemiology and Biology of a Novel Exceptional Aging Phenotype.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Article
- R4Alz-R: a cutting-edge tool for spotting the very first and subtle signs of aging-related cognitive impairment with high accuracy.GeroScience · 2025Article
- Aging, longevity, and healthy aging: the public health approach.Aging clinical and experimental research · 2025Review
- Evolvable Soma Theory of Ageing: insights from computer simulations.Biogerontology · 2025Article
- Can we detect cognitive "super-agers" in Parkinson's disease? Cognitive, neuropsychiatric and motor outcomes in the first 10 years of Parkinson's disease.Parkinsonism & related disorders · 2025Article
- Identification of key brain networks and functional connectivities of successful aging: A surface-based resting-state functional magnetic resonance study.World journal of psychiatry · 2025Article
- Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies.Brain sciences · 2025Review
- Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.Neurobiology of aging · 2025Review
- Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well.Biological psychiatry global open science · 2025Article
- Impact of individual differences in cognitive reserve, stress, and busyness on episodic memory: an fMRI analysis of the Alabama Brain Study On Risk for Dementia.Cognitive, affective & behavioral neuroscience · 2025Article
- Singing for memory: neural and cognitive effects of a choral intervention in older adults.Frontiers in aging neuroscience · 2025Article
- APOE4-related differences in cortical thickness are modulated by sex in middle age.Brain imaging and behavior · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSuperagers are older adults presenting excellent memory performance that may reflect resilience to the conventional pathways of aging. Our contribution aims to shape the evidence body of the known distinctive biomarkers of superagers and their connections with the Brain and Cognitive Reserve and Brain Maintenance concepts.
methodsWe performed a systematic literature search in PubMed and ScienceDirect with no limit on publication date for studies that evaluated potential biomarkers in superagers classified by validated neuropsychological tests. Methodological quality was assessed using the QUADAS-2 tool.
resultsTwenty-one studies were included, the majority in neuroimaging, followed by histological, genetic, cognition, and a single one on blood plasma analysis. Superagers exhibited specific regions of cortical preservation, rather than global cortical maintenance, standing out the anterior cingulate and hippocampus regions. Both superagers and controls showed similar levels of amyloid deposition. Moreover, the functional oscillation patterns in superagers resembled those described in young adults. Most of the quality assessment for the included studies showed medium risks of bias.
conclusionThis systematic review supports selective cortical preservation in superagers, comprehending regions of the default mode, and salience networks, overlapped by stronger functional connectivity. In this context, the anterior cingulate cortex is highlighted as an imaging and histologic signature of these subjects. Besides, the biomarkers included pointed out that the Brain and Cognitive Reserve and Brain Maintenance concepts are independent and complementary in the superagers' setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.