ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2021
OSA in patients with head and neck cancer is associated with cancer size and oncologic outcome.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Obstructive Sleep Apnea After Supracricoid Laryngeal Surgery (OPHL II): A Monocentric Prospective Pilot Study.Cancers · 2026Article
- Characteristics and associated factors of insomnia in gynecological cancer patients: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Oral Cancer and Sleep Disturbances: A Narrative Review on Exploring the Bidirectional Relationship.Cancers · 2025Review
- Sleep and Cancer.Cancers · 2025Review
- Survival and data-driven phenotypes in head and neck cancer.Scientific reports · 2025Article
- Treatment of obstructive sleep apnea with CPAP improves daytime sleepiness and fatigue in cancer patients.Cancer medicine · 2024Article
- Symptom impact and health-related quality of life (HRQoL) assessment by cancer stage: a narrative literature review.BMC cancer · 2024Review
- Prevalence of obstructive sleep apnea after treatment for advanced T-stage head and neck cancer.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Prevalence of Obstructive Sleep Apnea in Head and Neck Squamous Cell Carcinoma Patients before and after Treatment.Medicina (Kaunas, Lithuania) · 2024Article
- Patient Support in Obstructive Sleep Apnoea by a Large Language Model - ChatGPT 4o on Answering Frequently Asked Questions on First Line Positive Airway Pressure and Second Line Hypoglossal Nerve Stimulation Therapy: A Pilot Study.Nature and science of sleep · 2024Article
- Sleep disorders, sleep quality, and health-related quality of life in patients with cancer in Turkey: a multi-center cross-sectional survey.Ewha medical journal · 2024Article
- Comorbidities and Laryngeal Cancer in Patients with Obstructive Sleep Apnea: A Review.Medicina (Kaunas, Lithuania) · 2023Review
- Anatomic Features of the Nasal and Pharyngeal Region Do Not Influence PAP Therapy Response.International journal of environmental research and public health · 2023Article
- Serum Ferritin Levels in Severe Obstructive Sleep Apnea.Diagnostics (Basel, Switzerland) · 2023Article
- Short-Term Outcome of Unilateral Inspiration-Coupled Hypoglossal Nerve Stimulation in Patients with Obstructive Sleep Apnea.International journal of environmental research and public health · 2022Article
- Impact of free flap reconstruction on obstructive sleep apnea in patients with oral and oropharyngeal cancer.Asia-Pacific journal of oncology nursing · 2022Article
- Risk of obstructive sleep apnea after treatment of head and neck squamous cell carcinoma: a cross-sectional study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Cellular Immune Dysfunction in Obstructive Sleep Apnea.Frontiers in surgery · 2022Review
- Obstructive Sleep Apnea in Patients with Head and Neck Cancer-More than Just a Comorbidity?Medicina (Kaunas, Lithuania) · 2021Review
- Obstructive Sleep Apnea in Head and Neck Cancer Survivors: A Systematic Review and Meta-Analysis.OTO openReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObstructive sleep apnea (OSA) is associated with severe daytime sleepiness and reduced quality of life. These symptoms are also present in patients with squamous cell carcinoma of the head and neck (SCCHN) before, during and after treatment, so that comorbidity cannot be excluded. The aim was to evaluate the prevalence of OSA and its impact on the quality of life in patients with oropharyngeal, hypopharyngeal and lateral tongue SCCHN in a prospective study.
methodsWe performed cardiorespiratory home sleep apnea testing and recorded sleep-related patient-reported outcomes in 33 patients with confirmed oropharyngeal, hypopharyngeal and lateral tongue SCCHN. We correlated the sleep-related variables to oncologic variables and endpoints.
resultsFive female and 28 male patients with SCCHN (aged 46-77 years) were recruited. Thirty patients (90%) had OSA as defined by an Apnea/Hypopnea Index (AHI) > 5 /h before treatment. Evaluation after treatment, which was possible in 17 patients, showed OSA in 16 patients (94%). Radiologic primary tumor size showed significant positive correlation with AHI and apnea-index. Tumor recurrence and tumor-related mortality showed significant positive association with AHI. PSQI of these patients showed at least a moderate sleep disturbance. EORTC QLQ c30 questionnaire showed reduced values for all tested qualities, in particular for fatigue, insomnia, pain and financial distress.
conclusionObstructive sleep apnea is a significant comorbidity in patients with SCCHN. Pre-interventional AHI may be correlated with the oncologic outcome. Further research is needed to further describe the course of OSA and its treatment before, during and after therapy.
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