ArticleCerebral cortex (New York, N.Y. : 1991)2021
Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- State and parameter estimation for a neural model of local field potentials.Journal of mathematical biology · 2026Article
- Predictability of sleep slow oscillation emergence and spatial extent from pre-onset neural dynamics.Scientific reports · 2026Article
- Closed-loop acoustic stimulation modified by cathodal tDCS is beneficial for retention.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal indexing alters the stability landscape of synaptic weight space allowing life-long learning.bioRxiv : the preprint server for biology · 2025Article
- Transcranial near infrared therapy reprograms metabolism to rescue sleep and place cell functionality.iScience · 2025Article
- Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations.bioRxiv : the preprint server for biology · 2024Article
- Coordinated NREM sleep oscillations among hippocampal subfields modulate synaptic plasticity in humans.Communications biology · 2024Article
- Feasibility of a Personal Neuromorphic Emulation.Entropy (Basel, Switzerland) · 2024Article
- Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep.Software impacts · 2024Article
- Article
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
- Augmenting hippocampal-prefrontal neuronal synchrony during sleep enhances memory consolidation in humans.Nature neuroscience · 2023Article
- Multielectrode Cortical Stimulation Selectively Induces Unidirectional Wave Propagation of Excitatory Neuronal Activity in Biophysical Neural Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A model of autonomous interactions between hippocampus and neocortex driving sleep-dependent memory consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Pathological changes of brain oscillations following ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Article
- Role of Sleep in Formation of Relational Associative Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Human Spindle Variability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Single-neuron firing cascades underlie global spontaneous brain events.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Replay in Deep Learning: Current Approaches and Missing Biological Elements.Neural computation · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The dialogue between cortex and hippocampus is known to be crucial for sleep-dependent memory consolidation. During slow wave sleep, memory replay depends on slow oscillation (SO) and spindles in the (neo)cortex and sharp wave-ripples (SWRs) in the hippocampus. The mechanisms underlying interaction of these rhythms are poorly understood. We examined the interaction between cortical SO and hippocampal SWRs in a model of the hippocampo-cortico-thalamic network and compared the results with human intracranial recordings during sleep. We observed that ripple occurrence peaked following the onset of an Up-state of SO and that cortical input to hippocampus was crucial to maintain this relationship. A small fraction of ripples occurred during the Down-state and controlled initiation of the next Up-state. We observed that the effect of ripple depends on its precise timing, which supports the idea that ripples occurring at different phases of SO might serve different functions, particularly in the context of encoding the new and reactivation of the old memories during memory consolidation. The study revealed complex bidirectional interaction of SWRs and SO in which early hippocampal ripples influence transitions to Up-state, while cortical Up-states control occurrence of the later ripples, which in turn influence transition to Down-state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.