Evidence map›Paper›PMID 32995830›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report.

Jason D Goldman, Kai Wang, Katharina Röltgen, Sandra C A Nielsen, Jared C Roach, Samia N Naccache, Fan Yang, Oliver F Wirz, Kathryn E Yost, Ji-Yeun Lee and 20 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 7 institutions in 1 country.

Jason D GoldmanDivision of Infectious Diseases, Swedish Medical Center, Seattle, WA, USA.
Kai WangInstitute for Systems Biology, Seattle, WA, USA.
Katharina RöltgenDepartment of Pathology, Stanford University, Stanford, CA, USA.
Sandra C A NielsenDepartment of Pathology, Stanford University, Stanford, CA, USA.
Jared C RoachInstitute for Systems Biology, Seattle, WA, USA.
Samia N NaccacheDepartment of Microbiology, LabCorp, Seattle, WA, USA.
Fan YangDepartment of Pathology, Stanford University, Stanford, CA, USA.
Oliver F WirzDepartment of Pathology, Stanford University, Stanford, CA, USA.
Kathryn E YostDepartment of Pathology, Stanford University, Stanford, CA, USA.
Ji-Yeun LeeDepartment of Pathology, Stanford University, Stanford, CA, USA.
Kelly ChunLabCorp Esoterix, Calabasas, CA, USA.
Terri WrinMonogram Biosciences, South San Francisco, CA, USA.
Christos J PetropoulosMonogram Biosciences, South San Francisco, CA, USA.
Inyoul LeeInstitute for Systems Biology, Seattle, WA, USA.
Shannon FallenInstitute for Systems Biology, Seattle, WA, USA.
Paula M MannerSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, USA.
Julie A WallickSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, USA.
Heather A AlgrenSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, USA.
Kim M MurrayInstitute for Systems Biology, Seattle, WA, USA.
Yapeng SuInstitute for Systems Biology, Seattle, WA, USA.
Jennifer HadlockInstitute for Systems Biology, Seattle, WA, USA.
Joshua JeharajahDivision of Infectious Diseases, Polyclinic, Seattle, WA, USA.
William R BerringtonDivision of Infectious Diseases, Swedish Medical Center, Seattle, WA, USA.
George P PappasDivision of Pulmonology and Critical Care Medicine, Swedish Medical Center, Seattle, WA, USA.
Sonam T NyatsatsangDivision of Infectious Diseases, Swedish Medical Center, Seattle, WA, USA.
Alexander L GreningerDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA, USA.
John S PaukDivision of Infectious Diseases, Swedish Medical Center, Seattle, WA, USA.
Scott D BoydDepartment of Pathology, Stanford University, Stanford, CA, USA.
James R HeathInstitute for Systems Biology, Seattle, WA, USA.
Providence College · USStanford University · USInstitute for Systems Biology · USLabCorp (United States) · USPolyclinic Medical Center · USSwedish Medical Center · USUniversity of Washington · US

Funding

Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National StudyR01AI141953 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2019 to 2023
$5.7M
NIAID NIH HHS R01 AI141953
6 · The paper itself

Abstract

Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a new strain harboring the spike variant D614G. With antibody and B cell analytics, we show correlates of adaptive immunity, including a differential response to D614G. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.

Identifiers

PMID32995830
PMCPMC7523175
OpenAlexW3087983071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.