Evidence map›Paper›PMID 32995798›Full record

ArticlebioRxiv : the preprint server for biology2021

JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis.

Juhee Son, Shimeng Huang, Qiru Zeng, Traci L Bricker, James Brett Case, Jinzhu Zhou, Ruochen Zang, Zhuoming Liu, Xinjian Chang, Houda H Harastani and 18 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 7 institutions in 2 countries.

Juhee Son *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Shimeng Huang *Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Qiru Zeng *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Traci L BrickerDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
James Brett CaseDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Jinzhu ZhouInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Ruochen ZangDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Zhuoming LiuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Xinjian ChangInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Houda H HarastaniDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Lu ChenNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Maria Florencia Gomez CastroDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Yongxiang ZhaoInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Hinissan P KohioDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Gaopeng HouDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Baochao FanInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Beibei NiuInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Rongli GuoInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Paul W RothlaufDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Adam L BaileyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Xin WangKey Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao, China.
Pei-Yong ShiDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA.
Elisabeth D MartinezDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Sean P J WhelanDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Michael S DiamondDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Adrianus C M BoonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Bin LiInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Siyuan DingDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Washington University in St. Louis · USJiangsu Academy of Agricultural Sciences · CNHarvard University · USNational Institutes of Health · USOcean University of China · CNSouthwestern Medical Center · USThe University of Texas Medical Branch at Galveston · US

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
COVID Supplement B Cell Epitope Discovery and Mechanisms of Antibody Protection.75N93019C00062 · NIAID · WASHINGTON UNIVERSITY · PI FREMONT, DAVED · 2019 to 2023
$11.7M
Emerging infections: surveillance, epidemiology and pathogenesisU01AI151810 · NIAID · WASHINGTON UNIVERSITY · PI Adrianus CM Boon, DAVID WANG · 2020 to 2026
$10.0M
RNA Processing in Non-Segmented Minus-Strand RNA VirusesR37AI059371 · NIAID · WASHINGTON UNIVERSITY · PI WHELAN, SEAN PJ · 2015 to 2024
$5.4M
Human neutralizing antibodies for Zika virusR01AI127828 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2017 to 2021
$3.9M
Interferon-Stimulated Gene Inhibition of Rotavirus Replication and Viral AntagonismR01AI150796 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2024
$2.0M
Genetic and Biochemical Interrogation of Rotavirus-Cohesin InteractionR00AI135031 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2021
$498k
Epigenetic reprogramming of the malaria parasiteR21AI139408 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MARTINEZ, ELISABETH D · 2020 to 2021
$449k
Genetic and Biochemical Interrogation of Rotavirus-Cohesin InteractionK99AI135031 · NIAID · STANFORD UNIVERSITY · PI DING, SIYUAN · 2018 to 2018
$132k
NIAID NIH HHS 75N93019C00062NIAID NIH HHS K99 AI135031NIAID NIH HHS R00 AI135031NIAID NIH HHS R01 AI127828NIAID NIH HHS R01 AI150796NIAID NIH HHS R21 AI139408NIAID NIH HHS R37 AI059371NIAID NIH HHS U01 AI151810NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

Pathogenic coronaviruses represent a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified several small-molecule inhibitors that potently block the replication of the newly emerged severe acute respiratory syndrome virus 2 (SARS-CoV-2). Among them, JIB-04 inhibited SARS-CoV-2 replication in Vero E6 cells with an EC

Identifiers

PMID32995798
PMCPMC7523209
OpenAlexW3088364701

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.