Evidence map›Paper›PMID 32995789›Full record

ArticlebioRxiv : the preprint server for biology2020

Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication.

Jennifer S Chen, Mia Madel Alfajaro, Jin Wei, Ryan D Chow, Renata B Filler, Stephanie C Eisenbarth, Craig B Wilen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 43 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jennifer S ChenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Mia Madel AlfajaroDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Jin WeiDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Ryan D ChowDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Renata B FillerDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Stephanie C EisenbarthDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Craig B WilenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Role of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940k
Mechanosensation in tumorigenesis and metastasisF30CA250249 · NCI · YALE UNIVERSITY · PI CHOW, RYAN D · 2020 to 2022
$113k
Regulation of T cell-derived cytokines in allergic airway inflammationF30HL149151 · NHLBI · YALE UNIVERSITY · PI CHEN, JENNIFER S · 2020 to 2022
$113k
NCATS NIH HHS UL1 TR001863NCI NIH HHS F30 CA250249NHLBI NIH HHS F30 HL149151NIAID NIH HHS K08 AI128043NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Identifying drugs that regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its symptoms has been a pressing area of investigation during the coronavirus disease 2019 (COVID-19) pandemic. Nonsteroidal anti-inflammatory drugs (NSAIDs), which are frequently used for the relief of pain and inflammation, could modulate both SARS-CoV-2 infection and the host response to the virus. NSAIDs inhibit the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which mediate the production of prostaglandins (PGs). PGE

Identifiers

PMID32995789
PMCPMC7523115
OpenAlexW3088895409

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.