Evidence map›Paper›PMID 32995743›Full record

ArticleMaterials today. Bio2020

An open-source handheld extruder loaded with pore-forming bioink for

G Ying, J Manríquez, D Wu, J Zhang, N Jiang, S Maharjan, D H Hernández Medina, Y S Zhang

Abstract read
In one paragraph

Article in Materials today. Bio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
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  5. Article
  6. Review
  7. Development and Quantitative Evaluation of a Novel AutonomousIEEE transactions on automation science and engineering : a publication of the IEEE Robotics and Automation Society · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Acta pharmaceutica Sinica. B · 2024
    Review
  15. An Adhesive Bioink toward Biofabrication under Wet Conditions.Small (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  16. A novel portableAPL bioengineering · 2023
    Article
  17. Bioactive materials · 2023
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

G YingDivision of Engineering of Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
J ManríquezDivision of Engineering of Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
D WuDivision of Engineering of Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
J ZhangDivision of Engineering of Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
N JiangSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
S MaharjanDivision of Engineering of Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
D H Hernández MedinaDivision of Engineering of Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Y S ZhangDivision of Engineering of Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.

Funding

Handheld Wound Analyzer for in situ HealingR01GM134036 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2020 to 2023
$1.4M
Developing Hybrids of Cardiac Tissue and Biodegradable Electronics Towards Heart Implants with On-line Monitoring and Stimulating FunctionsR21EB026175 · NIBIB · UNIVERSITY OF HOUSTON · PI YU, CUNJIANG · 2018 to 2019
$468k
NIBIB NIH HHS R21 EB026175NIGMS NIH HHS R01 GM134036
6 · The paper itself

Abstract

The increasing demand in rapid wound dressing and healing has promoted the development of intraoperative strategies, such as intraoperative bioprinting, which allows deposition of bioinks directly at the injury sites to conform to their specific shapes and structures. Although successes have been achieved to varying degrees, either the instrumentation remains complex and high-cost or the bioink is insufficient for desired cellular activities. Here, we report the development of a cost-effective, open-source handheld bioprinter featuring an ergonomic design, which was entirely portable powered by a battery pack. We further integrated an aqueous two-phase emulsion bioink based on gelatin methacryloyl with the handheld system, enabling convenient shape-controlled in situ bioprinting. The unique pore-forming property of the emulsion bioink facilitated liquid and oxygen transport as well as cellular proliferation and spreading, with an additional ability of good elasticity to withstand repeated mechanical compressions. These advantages of our pore-forming bioink-loaded handheld bioprinter are believed to pave a new avenue for effective wound dressing potentially in a personalized manner down the future.

Indexed as

BioprintingGelatin methacryloyl (GelMA)IntraoperativeMinimally invasivePolyethylene oxide (PEO)Porous

Identifiers

PMID32995743
PMCPMC7508999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.