Evidence map›Paper›PMID 32995726›Full record

ReviewCJC open2020

Update to Evidence-Based Secondary Prevention Strategies After Acute Coronary Syndrome.

David H Fitchett, Lawrence A Leiter, Peter Lin, Jennifer Pickering, Robert Welsh, James Stone, Jean Gregoire, Philip McFarlane, Anatoly Langer, Anil Gupta and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in CJC open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

David H FitchettSt Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Lawrence A LeiterSt Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Peter LinCanadian Heart Research Center, Toronto, Ontario, Canada.
Jennifer PickeringHamilton Heath Sciences, Hamilton, Ontario, Canada.
Robert WelshCanadian VIGOUR Centre, University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.
James StoneUniversity of Calgary, Calgary, Alberta, Canada.
Jean GregoireMontreal Heart Centre, University of Montreal, Montreal, Quebec, Canada.
Philip McFarlaneSt Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Anatoly LangerSt Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Anil GuptaTrillium Health Partners, Mississauga, Ontario, Canada.
Shaun G GoodmanSt Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Canadian Heart Research Centre · CASt. Michael's Hospital · CACanadian VIGOUR Centre · CAHamilton Health Sciences · CAMontreal Heart Institute · CATrillium Health Centre · CAUniversity of Calgary · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A recent acute coronary syndrome provides an opportunity to optimise secondary prevention strategies to reduce the risk of future cardiovascular events. This review provides an updated synopsis of current evidence-based approaches. New clinical trial data on the use of antiplatelet and anticoagulants allow choices of the selection and duration of treatment. Lipid lowering after an acute coronary syndrome is now enhanced, with proprotein convertase subtilisin-kexin type 9 inhibitors providing added benefit on top of statin and ezetimibe treatment in high-risk patients. In addition, a recent trial of icosapent ethyl, a highly purified ethyl ester of eicosapentaenoic acid, addresses residual risk in patients with elevated triglycerides already treated with statins. The use of both sodium-glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes reduces cardiovascular events independently of glucose lowering.

Identifiers

PMID32995726
PMCPMC7499366
OpenAlexW3016102083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.