ArticleSynthetic biology (Oxford, England)2018
Hybrid semiparametric systems for quantitative sequence-activity modeling of synthetic biological parts.
Article in Synthetic biology (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Predicting the activity of modified biological parts is difficult due to the typically large size of nucleotide sequences, resulting in combinatorial designs that suffer from the "curse of dimensionality" problem. Mechanistic design methods are often limited by knowledge availability. Empirical methods typically require large data sets, which are difficult and/or costly to obtain. In this study, we explore for the first time the combination of both approaches within a formal hybrid semiparametric framework in an attempt to overcome the limitations of the current approaches. Protein translation as a function of the 5' untranslated region sequence in
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