Evidence map›Paper›PMID 32995506›Full record

ArticleSynthetic biology (Oxford, England)2017

Translation inhibition and resource balance in the TX-TL cell-free gene expression system.

Vijayalakshmi H Nagaraj, James M Greene, Anirvan M Sengupta, Eduardo D Sontag

Abstract read
In one paragraph

Article in Synthetic biology (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Reconstituting alternative life using the test-bed of cell-free systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  2. Article
  3. Frontiers in cell and developmental biology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Bacterial cell-free expression technology toSynthetic and systems biotechnology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vijayalakshmi H NagarajDepartment of Physics and Astronomy, Center for Quantitative Biology (CQB), Rutgers University, Piscataway, NJ, USA.
James M GreeneDepartment of Mathematics and CQB, Rutgers University, Piscataway, NJ, USA.
Anirvan M SenguptaDepartment of Physics and Astronomy and CQB, Rutgers University, Piscataway, NJ, USA.
Eduardo D SontagDepartment of Mathematics and CQB, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0001-8020-5783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantifying the effect of vital resources on transcription (TX) and translation (TL) helps to understand the degree to which the concentration of each resource must be regulated for achieving homeostasis. Utilizing the synthetic TX-TL system, we study the impact of nucleotide triphosphates (NTPs) and magnesium (Mg

Indexed as

cell-free systemshomeostasisin vitro synthetic biologyRNA aptamertranslation rate

Identifiers

PMID32995506
PMCPMC7445783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.