ArticleNature reviews. Chemistry2019
Dirhodium tetracarboxylates as catalysts for selective intermolecular C-H functionalization.
Article in Nature reviews. Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed.
- Bridged scaffold editing of carbocycles and heterocycles.Nature communications · 2026Article
- Enantioselective Pyrazole Alkylation via Iridium and Squaramide Catalyzed N-H Insertion.Journal of the American Chemical Society · 2026Article
- Asymmetric Catalysis: Recent Advances toward a More Sustainable Synthesis.ACS central science · 2026Review
- Enantioselective Synthesis of Axially Chiral Spiro[3.3]heptanes by Site-Selective C-H Functionalization.ACS catalysis · 2026Article
- Stereoselective total synthesis of skew-tetramantane.Nature chemistry · 2026Article
- Enantioselective C-H functionalization: logic and applications in the total synthesis of natural products.Chemical science · 2026Review
- Asymmetric C-H Functionalization of Bicyclo[2.1.1]hexanes and Their 2-Oxa- and 2-Aza Derivatives via Rhodium Carbene Intermediates.Journal of the American Chemical Society · 2026Article
- Properties of Bisdiazo Compounds and Their Derived Carbenes via Density Functional Theory.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Coordination of a Dirhodium(II) Center to Methionine and Cysteine Side Chains: Evidence from X-Ray Structure of the Adduct Formed by Dirhodium Tetraacetate with a C-Phycocyanin.International journal of molecular sciences · 2025Article
- Head-tail carboboration of multisubstituted alkenes enabled by chain recognition.Nature chemistry · 2025Article
- Enantioselective and Diastereoselective Synthesis of Azaspiro[n.2]alkanes by Rhodium-Catalyzed Cyclopropanations.ACS catalysis · 2025Article
- Migrating Group Strategy for Remote Functionalization of Seven-Membered Rings.Journal of the American Chemical Society · 2025Article
- Catalytic aromatic C-H borylation via strained Si and Ge metallacycles.Nature communications · 2025Article
- Future Trends in Asymmetric Organo-Metal Combined Catalysis.ACS central science · 2025Review
- Asymmetric C-H Functionalization ofJournal of the American Chemical Society · 2025Article
- Rh-Catalyzed Atroposelective Single-Carbon Insertion.Journal of the American Chemical Society · 2025Article
- Impact of Induced Fitting and Secondary Noncovalent Interactions on Site-Selective and Enantioselective C-H Functionalization of Arylcyclohexanes.Journal of the American Chemical Society · 2025Article
- [2,3]-Sigmatropic rearrangement with [1.1.1]propellane.Nature communications · 2025Article
- Breaking Bonds, Breaking Paradigms: Critical Insights into Inner-Sphere C(spTopics in current chemistry (Cham) · 2025Review
- Iron-catalyzed aliphatic C-H functionalization to construct carbon-carbon bonds.Nature communications · 2025Article
41 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
C-H Functionalization has become widely recognized as an exciting new strategy for the synthesis of complex molecular targets. Instead of relying on functional groups as the controlling elements of how molecules are assembled, it offers a totally different logic for organic synthesis. For this type of strategy to be successful, reagents and catalysts need to be developed that generate intermediates that are sufficiently reactive to functionalize C-H bonds but still capable of distinguishing between the different C-H bonds and other functional groups present in a molecule. The most well-established approaches have tended to use substrates that have inherently a favored site for C-H functionalization or rely on intramolecular reactions to control where the reaction will occur. A challenging but potentially more versatile approach would be to use catalysts to control the site-selectivity without requiring the influence of any directing group. One example that is capable of achieving such transformations is the C-H insertion chemistry of transient metal carbenes. Dirhodium tetracarboxylates have been shown to be especially effective catalysts for these reactions. This review will highlight the development of these dirhodium catalysts and illustrate their effectiveness to control both site-selective and stereoselective C-H functionalization of a wide variety of substrates.
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