ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Cognitive indicators of transition to preclinical and prodromal stages of Alzheimer's disease in Down syndrome.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Early Markers for Dementia in the Intellectual Disability Population: A Systematic Literature Review.Journal of applied research in intellectual disabilities : JARID · 2025Pooled it
- Evaluating Scoring Mechanisms for Measuring the Stroop Effect in Individuals With Down Syndrome.Journal of intellectual disability research : JIDR · 2026Review
- Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome.Neurology · 2026Article
- Distinct brain regions are affected by neurodevelopmental or pre-dementia changes in Down syndrome.Brain communications · 2026Article
- Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Discrepancies in assessing intellectual disability levels in adults with Down syndrome: Implications for dementia diagnosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Current advances and unmet needs in Alzheimer's disease trials for individuals with Down syndrome: Navigating new therapeutic frontiers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome.Journal of neurodevelopmental disorders · 2025Article
- Brain outcomes with lifestyle change in adults with Down syndrome: Rationale and design for a 12-month randomized trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Preliminary investigation of obstructive sleep apnea and Alzheimer's disease in down syndrome.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Sex-related differences in genetically determined Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- Does Employment Complexity Promote Healthy Cognitive Aging in Down Syndrome?Journal of intellectual disabilities : JOID · 2024Article
- AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Characterizing the emergence of amyloid and tau burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study.The Lancet. Neurology · 2023Article
- Timing of Alzheimer's Disease by Intellectual Disability Level in Down Syndrome.Journal of Alzheimer's disease : JAD · 2023Article
- Weight Loss and Alzheimer's Disease in Down Syndrome.Journal of Alzheimer's disease : JAD · 2023Article
- Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome.Neurobiology of aging · 2022Article
- Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease.Alzheimer's research & therapy · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionThere is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer's disease (AD) pathophysiology in Down syndrome to advance clinical trial research in this at-risk population. The objective of the study was to longitudinally track performance on cognitive measures in relation to neocortical and striatal amyloid beta (Aβ) in non-demented Down syndrome.
methodsThe study included 118 non-demented adults with Down syndrome who participated in two to five points of data collection, spanning 1.5 to 8 years. Episodic memory, visual attention and executive functioning, and motor planning and coordination were assessed. Aβ was measured via [C-11] Pittsburgh Compound-B (PiB) PET.
resultsPiB was associated with level and rate of decline in cognitive performance in episodic memory, visual attention, executive functioning, and visuospatial ability in models controlling for chronological age. DISCUSSION: The Cued Recall Test emerged as a promising indicator of transition from preclinical to prodromal AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.