Evidence map›Paper›PMID 32995348›Full record

ArticleOpen forum infectious diseases2020

Cardiovascular Disease Risk Management in Persons With HIV: Does Clinician Specialty Matter?

Nwora Lance Okeke, Katherine R Schafer, Eric G Meissner, Jan Ostermann, Ansal D Shah, Brian Ostasiewski, Evan Phelps, Curtis A Kieler, Eniola Oladele, Keva Garg and 3 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nwora Lance OkekeDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-4456-0176
Katherine R SchaferDivision of Infectious Diseases, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Eric G MeissnerDivision of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Jan OstermannDepartment of Health Services Policy and Management, University of South Carolina Arnold School of Public Health, Columbia, South Carolina, USA.
Ansal D ShahDivision of Infectious Diseases, Prisma Health/University of South Carolina, Columbia, South Carolina, USA.
Brian OstasiewskiCenter for Biomedical Informatics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Evan PhelpsHealth Sciences South Carolina, Columbia, South Carolina, USA.
Curtis A KielerOffice of Academic Solutions and Information Systems, Duke University Medical Center, Durham, North Carolina, USA.
Eniola OladeleOffice of Academic Solutions and Information Systems, Duke University Medical Center, Durham, North Carolina, USA.
Keva GargDepartment of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Susanna NaggieDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7721-6975
Gerald S BloomfieldDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Hayden B BosworthDepartment of Population Health Sciences, Duke University, Durham, North Carolina, USA.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI STEPHEN A DUNCAN · 2020 to 2026
$18.7M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
A Clinic-Based Behavioral Intervention to Reduce Cardiovascular Disease Risk in Persons Living with HIVK23HL137611 · NHLBI · DUKE UNIVERSITY · PI OKEKE, NWORA LANCE · 2018 to 2022
$895k
Elucidating Mechanisms of Treatment Relapse for Interferon-Free HCV TherapyK08AI121348 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MEISSNER, ERIC G. · 2016 to 2020
$873k
NCATS NIH HHS UL1 TR001420NHLBI NIH HHS K23 HL137611NIAID NIH HHS K08 AI121348NIAID NIH HHS P30 AI064518NIDDK NIH HHS P30 DK123704NIGMS NIH HHS P20 GM130457
6 · The paper itself

Abstract

backgroundThe impact of clinician specialty on cardiovascular disease risk factor outcomes among persons with HIV (PWH) is unclear.

methodsPWH receiving care at 3 Southeastern US academic HIV clinics between January 2014 and December 2016 were retrospectively stratified into 5 groups based on the specialty of the clinician managing their hypertension or hyperlipidemia. Patients were followed until first atherosclerotic cardiovascular disease event, death, or end of study. Outcomes of interest were meeting 8th Joint National Commission (JNC-8) blood pressure (BP) goals and National Lipid Association (NLA) non-high-density lipoprotein (HDL) goals for hypertension and hyperlipidemia, respectively. Point estimates for associated risk factors were generated using modified Poisson regression with robust error variance.

resultsOf 1667 PWH in the analysis, 965 had hypertension, 205 had hyperlipidemia, and 497 had both diagnoses. At study start, the median patient age was 52 years, 66% were Black, and 65% identified as male. Among persons with hypertension, 24% were managed by an infectious diseases (ID) clinician alone, and 5% were co-managed by an ID clinician and a primary care clinician (PCC). Persons managed by an ID clinician were less likely to meet JNC-8 hypertension targets at the end of observation than the rest of the cohort (relative risk [RR], 0.84; 95% CI, 0.75-0.95), but when mean study blood pressure was considered, there was no difference between persons managed by ID and the rest of the cohort (RR, 0.96; 95% CI, 0.88-1.05). There was no significant association between the ID clinician managing hyperlipidemia and meeting NLA non-HDL goals (RR, 0.89; 95% CI, 0.68-1.15).

conclusionsClinician specialty may play a role in suboptimal hypertension outcomes in persons with HIV.

Indexed as

cardiovascular diseasehealth servicesHIVhyperlipidemiahypertension

Identifiers

PMID32995348
PMCPMC7507875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.