Evidence map›Paper›PMID 32995118›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Penetrable Nanoplatform for "Cold" Tumor Immune Microenvironment Reeducation.

Qinjun Chen, Yongqing He, Yu Wang, Chao Li, Yujie Zhang, Qin Guo, Yiwen Zhang, Yongchao Chu, Peixin Liu, Hongyi Chen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
  2. Review
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  6. Phototherapy in cancer treatment: strategies and challenges.Signal transduction and targeted therapy · 2025
    Review
  7. Review
  8. Article
  9. Optogenetically engineered Septin-7 enhances immune cell infiltration of tumor spheroids.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Hybrid Nanomaterials for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Qinjun ChenKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Yongqing HeKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Yu WangKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Chao LiKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Yujie ZhangKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Qin GuoKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Yiwen ZhangKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Yongchao ChuKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Peixin LiuKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Hongyi ChenKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Zheng ZhouKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Wenxi ZhouKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Zhenhao ZhaoKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Xiaomin LiDepartment of Chemistry and Laboratory of Advanced Materials Fudan University Shanghai 200433 P. R. China.
Tao SunKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.
Chen JiangKey Laboratory of Smart Drug Delivery (Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Research Center on Aging and Medicine Fudan University Shanghai 201203 P. R. China.ORCID https://orcid.org/0000-0001-5223-2725
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lack of tumor-infiltration lymphocytes (TILs) and resistances by overexpressed immunosuppressive cells (principally, myeloid-derived suppressor cells (MDSCs)) in tumor milieu are two major challenges hindering the effectiveness of immunotherapy for "immune-cold" tumors. In addition, the natural physical barrier existing in solid cancer also limits deeper delivery of drugs. Here, a tumor-targeting and light-responsive-penetrable nanoplatform (Apt/PDGs

Indexed as

antitumor immune responsesimmunogenic cell deathimmunosuppressionmetal–organic frameworkspenetration

Identifiers

PMID32995118
PMCPMC7503208
OpenAlexW3046338067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.