ArticleFood science & nutrition2020
Antioxidant and hepatorenal protective effects of bee pollen fractions against propionic acid-induced autistic feature in rats.
Article in Food science & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Alleviation of Aflatoxin B1-Induced Hepatic Damage by Propolis: Effects on Inflammation, Apoptosis, and Cytochrome P450 Enzyme Expression.Current issues in molecular biology · 2026Article
- Evaluation of the Hepatoprotective Efficacy of Bee Pollen and Bee Pollen Ethanolic Extract-Loaded Solid Lipid Nanoparticles Against Lead Acetate-Induced Hepatotoxicity in Male Wistar Rats.BioMed research international · 2026Article
- Protective Effects of Propolis Supplementation on Aflatoxin B1-Induced Oxidative Stress, Antioxidant Status, Intestinal Barrier Damage, and Gut Microbiota in Rats.Molecular nutrition & food research · 2025Article
- Polyphenol Profile and Antioxidant, Antityrosinase, and Anti-Melanogenesis Activities of Ethanol Extract of Bee Pollen.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Pathophysiological mechanisms of complications associated with propionic acidemia.Pharmacology & therapeutics · 2023Review
- Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World.Nutrients · 2023Article
- Calcium voltage-gated channel subunit alpha 1 C and glial fibrillary acidic protein signaling pathways as a selective biomarker in predicting the efficacy of liposomal loaded co-enzyme Q in the autistic rat model.Toxicology reports · 2023Article
- Plasma Metabolomic Analysis Reveals the Relationship between Immune Function and Metabolic Changes in Holstein Peripartum Dairy Cows.Metabolites · 2022Article
- Protective Effects of Bee Pollen on Multiple Propionic Acid-Induced Biochemical Autistic Features in a Rat Model.Metabolites · 2022Article
- Association of Maternal Diabetes and Autism Spectrum Disorders in Offspring: a Study in a Rodent Model of Autism.Journal of molecular neuroscience : MN · 2022Article
- Optimisation of Bee Pollen Extraction to Maximise Extractable Antioxidant Constituents.Antioxidants (Basel, Switzerland) · 2021Article
- Antioxidant and hepatorenal protective effects of bee pollen fractions against propionic acid-induced autistic feature in rats.Food science & nutrition · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the brain, propionic acid (PA) can cross cell membranes and accumulate within cells, leading to intracellular acidification, which may alter neurotransmitter release (NT), communication between neurons, and behavior. Such elevation in levels of PA constitutes a neurodevelopmental metabolic disorder called propionic acidemia, which could clinically manifest as autism. The purpose of this study was to investigate the protective effects of different fractions of bee pollen (BP) on PA-induced autism in rats, and to evaluate their effects on the expression of liver and renal biomarkers. Groups of rats received treatments of different fractions of BP at a dose of 250 mg/kg of body weight/day for a period of 1 month. Normal control group I and group II were orally administered with phosphate-buffered saline and propionic acid, respectively, for 3 days. BP contains various health-promoting phenolic components. Different fractions of BP administered pre- and post-treatment with PA showed significant reduction in the levels of liver and renal biomarkers (
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