Evidence map›Paper›PMID 32994821›Full record

ArticleOncology letters2020

Hydrogen gas activates coenzyme Q10 to restore exhausted CD8

Junji Akagi, Hideo Baba

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management.Asian Pacific journal of cancer prevention : APJCP · 2023
    Pooled it
  2. Review
  3. Research progress in clinical utilization of HFrontiers in pharmacology · 2026
    Review
  4. Mitochondrial Metabolism in T-Cell Exhaustion.International journal of molecular sciences · 2025
    Review
  5. Molecular Hydrogen in the Treatment of Respiratory Diseases.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Review
  8. The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Review
  11. Prospects of molecular hydrogen in cancer prevention and treatment.Journal of cancer research and clinical oncology · 2024
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Mechanisms and Application of Gas-Based Anticancer Therapies.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  17. Review
  18. Review
  19. Article
  20. Molecular hydrogen is a promising therapeutic agent for pulmonary disease.Journal of Zhejiang University. Science. B · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Junji AkagiDepartment of Surgery, Tamana Regional Health Medical Center, Kumamoto 865-0005, Japan.
Hideo BabaDepartment of Gastroenterological Surgery Kumamoto University, Kumamoto 860-8556, Japan.
Kumamoto Medical Center · JPKumamoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8

Indexed as

coenzyme Q10hydrogen gaslung cancerNivolumabT cell immunoglobulin and mucin domain-containing protein 3

Identifiers

PMID32994821
PMCPMC7509685
OpenAlexW3087588976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.