Evidence map›Paper›PMID 32994739›Full record

ArticleSaudi journal of biological sciences2020

A study on the potential reprotoxic effects of thimerosal in male albino rats.

Muhammad Umar Ijaz, Moazama Batool, Asma Ashraf, Muhammad Hussnain Siddique, Sara Zafar, Saima Muzammil, Fatima Ayaz, Abdul Samad, Khalid Al-Ghanim, Shahid Mahboob

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In one paragraph

Article in Saudi journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Muhammad Umar IjazDepartment of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan.
Moazama BatoolDepartment of Zoology, Govt. College Women University, Sialkot, Pakistan.
Asma AshrafDepartment of Zoology, Government College University, Faisalabad, Pakistan.
Muhammad Hussnain SiddiqueDepartment of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Sara ZafarDepartment of Botany, Government College University, Faisalabad, Pakistan.
Saima MuzammilDepartment of Microbiology, Government College University, Faisalabad, Pakistan.
Fatima AyazDepartment of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan.
Abdul SamadDepartment of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan.
Khalid Al-GhanimDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Shahid MahboobDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Government College University, Faisalabad · PKUniversity of Agriculture Faisalabad · PKKing Saud University · SAGovernment College Women University Sialkot

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thimerosal is ethyl mercury based compound which is being used as a preservative in vaccines since decades. Pharmaceutical products and vaccines that contain thimerosal are among the potential source of mercury exposure. Current research was intended to ascertain the reprotoxic effects of thimerosal on rat testes. Twenty-four adult male albino rats were sorted into four groups (n = 6). The first group was a control group. Rats of experimental Group 2, 3 and 4 were treated with various dosages of thimerosal (0.5, 10, 50 mg/kg) respectively. Rats were decapitated after thirty days of trial and different parameters were analyzed. Thimerosal exposure resulted in a significant decrease in antioxidant enzyme activities including catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), glutathione reductase (GSR) and increased levels of thiobarbituric acid reactive substances (TBARS). Different doses of thimerosal significantly decreased (p < 0.05) the concentration of plasma testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH). Additionally, Daily sperm production (DSP) and efficiency of daily sperm production were significantly reduced followed by thimerosal exposure. Moreover, thimerosal significantly (p < 0.05) decreased the primary spermatocytes, secondary spermatocytes, number of spermatogonia along with spermatids. Thimerosal induced adverse histopathological and morphological changes in testicular tissues such as decreased Leydig cells, diameter of seminiferous tubules, tunica albuginea height and epithelial height. On the other hand, the increase in tubular lumen and interstitial spaces was observed due to thimerosal. These outcomes indicated that thimerosal has potential reprotoxic effects in male albino rats.

Indexed as

Antioxidant enzymesEthyl mercuryReprotoxicThimerosal

Identifiers

PMID32994739
PMCPMC7499386
OpenAlexW3038822885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.