Evidence map›Paper›PMID 32994682›Full record

ArticleBioinformation2020

Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant.

Jayaraman Selvaraj, Hussain Sardar, Veeraraghavan Vishnupriya, Janardhana Papayya Balakrishna, Surapaneni Krishna Mohan, Rajamanickam Pon Nivedha, Periyasamy Vijayalakshmi, Rajagopal Ponnulakshmi

Abstract read
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In one paragraph

Article in Bioinformation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jayaraman SelvarajDepartment of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
Hussain SardarDepartment of Biotechnology, Government Science College, Chitradurga-577501, Karnataka, India.
Veeraraghavan VishnupriyaDepartment of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
Janardhana Papayya BalakrishnaDepartment of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor, 10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, India.
Surapaneni Krishna MohanDepartment of Biochemistry and Department of Clinical Skills and Simulation, Panimalar Medical College Hospital and Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India.
Rajamanickam Pon NivedhaExonn Biosciences, Ticel Bio Park, Chennai-600 0113, India.
Periyasamy VijayalakshmiPG and Research Department of Biotechnology and Bioinformatics, Holy Cross College (Autonomous), Trichy- 620002, Tamil Nadu, India.
Rajagopal PonnulakshmiCentral Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymnemasaponin 5, Gymnemasin D, Gymnemoside A, Gymnemoside E, Gymnemoside F) derived from the Australian cowplant as the poteinal inhibitors of Amyloid precursor protein with optimal binding features for further consideration.

Indexed as

Alzheimer's diseaseGymnema sylvestreMolecular dockingProtein Network analysis

Identifiers

PMID32994682
PMCPMC7505243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.