Evidence map›Paper›PMID 32994530›Full record

ArticleScientific reports2020

Preclinical dosimetry models and the prediction of clinical doses of novel positron emission tomography radiotracers.

Adam A Garrow, Jack P M Andrews, Zaniah N Gonzalez, Carlos A Corral, Christophe Portal, Timaeus E F Morgan, Tashfeen Walton, Ian Wilson, David E Newby, Christophe Lucatelli and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. CXCR4-targeted PET imaging of glioblastoma using [EJNMMI radiopharmacy and chemistry · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Dosimetry of a NovelCancers · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adam A GarrowPreclinical PET-CT Facility, Edinburgh Imaging, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Jack P M AndrewsUniversity/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK.
Zaniah N GonzalezPreclinical PET-CT Facility, Edinburgh Imaging, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Carlos A CorralPreclinical PET-CT Facility, Edinburgh Imaging, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Christophe PortalEdinburgh Molecular Imaging (EMI), Nine Edinburgh Bioquarter, Edinburgh, EH16 4UX, UK.
Timaeus E F MorganPreclinical PET-CT Facility, Edinburgh Imaging, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Tashfeen WaltonPreclinical PET-CT Facility, Edinburgh Imaging, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Ian WilsonEdinburgh Molecular Imaging (EMI), Nine Edinburgh Bioquarter, Edinburgh, EH16 4UX, UK.
David E NewbyPreclinical PET-CT Facility, Edinburgh Imaging, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Christophe LucatelliPreclinical PET-CT Facility, Edinburgh Imaging, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Adriana A S TavaresPreclinical PET-CT Facility, Edinburgh Imaging, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. adriana.tavares@ed.ac.uk.

Funding

British Heart Foundation CH/09/002British Heart Foundation FS/17/51/33096British Heart Foundation FS/17/52/33096British Heart Foundation FS/19/34/34354British Heart Foundation PG/17/83/33370British Heart Foundation RE/13/3/30183British Heart Foundation RE/18/5/34216British Heart Foundation RG/16/10/32375
6 · The paper itself

Abstract

Dosimetry models using preclinical positron emission tomography (PET) data are commonly employed to predict the clinical radiological safety of novel radiotracers. However, unbiased clinical safety profiling remains difficult during the translational exercise from preclinical research to first-in-human studies for novel PET radiotracers. In this study, we assessed PET dosimetry data of six

Indexed as

Administration, IntravenousAnimalsBiasFemaleFluorine RadioisotopesFluorodeoxyglucose F18HumansMaleModels, AnimalPositron-Emission TomographyRadiometryRatsWhole Body ImagingFluorine-18Fluorine RadioisotopesFluorodeoxyglucose F18

Identifiers

PMID32994530
PMCPMC7525662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.