ArticleScientific reports2020
Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca
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Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Photoreceptor-targeted engineered exosomes encapsulating black phosphorus quantum dots for alleviating photoreceptor degeneration.Journal of nanobiotechnology · 2026Article
- Mechanistic basis of EMRE's essential role in the regulation of mitochondrial calcium uniporter complex.bioRxiv : the preprint server for biology · 2026Article
- Dysfunction of α2δ4 leads to photoreceptor degeneration through disrupted synaptic mitochondria and calcium crosstalk.Cell death & disease · 2026Article
- Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish.Communications biology · 2026Article
- Retinopathy-associated inosine monophosphate dehydrogenase 1 mutations cause metabolic and filament defects in cones.Disease models & mechanisms · 2025Article
- MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology.Journal of advanced research · 2025Review
- Activity-dependent mitochondrial ROS signaling regulates recruitment of glutamate receptors to synapses.eLife · 2024Article
- Increased cytotoxicity of PbEnvironmental science. Processes & impacts · 2023Article
- Beyond the matrix: structural and physiological advancements in mitochondrial calcium signaling.Biochemical Society transactions · 2023Review
- Thyroid hormone disorder and the heart: The role of cardiolipin in calcium handling.Experimental physiology · 2023Article
- Article
- Mitochondrial CaCommunications biology · 2022Article
- Genome-Wide Identification of Wild Soybean Mitochondrial Calcium Uniporter Family Genes and Their Responses to Cold and Carbonate Alkaline Stresses.Frontiers in plant science · 2022Article
- A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells.The Journal of biological chemistry · 2022Article
- Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart.Cell reports · 2021Article
- Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection.Annual review of vision science · 2021Review
- Metabolism in the Zebrafish Retina.Journal of developmental biology · 2021Review
- Zebrafish Models of Photoreceptor Dysfunction and Degeneration.Biomolecules · 2021Review
- Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans.Frontiers in cellular neuroscience · 2021Review
- Dynamic Control of Mitochondrial CaFrontiers in cell and developmental biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Celia M BisbachBiochemistry Department, University of Washington, Seattle, WA, USA.
Rachel A HuttoBiochemistry Department, University of Washington, Seattle, WA, USA.
Deepak PoriaDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Whitney M CleghornBiochemistry Department, University of Washington, Seattle, WA, USA.
Fatima AbbasOphthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA.
Frans VinbergOphthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA.
Vladimir J KefalovDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.
James B HurleyBiochemistry Department, University of Washington, Seattle, WA, USA.
Susan E BrockerhoffBiochemistry Department, University of Washington, Seattle, WA, USA. sbrocker@uw.edu.
University of Washington · USUniversity of Utah · US
Funding
WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Steven Bassnett · 1985 to 2026
$18.4MROD AND CONE RESPONSE CHARACTERISTICSR01EY006641 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1986 to 2026
$10.2MControl of Photoreceptor MetabolismR01EY017863 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 2007 to 2026
$6.4MPhotoreceptor Mitochondria and Ca2+ DynamicsR01EY026020 · NEI · UNIVERSITY OF WASHINGTON · PI BROCKERHOFF, SUSAN E, HURLEY, JAMES BRYANT · 2016 to 2024
$3.6MOpsin signaling in mammalian rod photoreceptorsR01EY030912 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV, PALCZEWSKI, KRZYSZTOF · 2020 to 2023
$1.6MCALCIUM HOMEOSTASIS IN MAMMALIAN ROD AND CONE PHOTORECEPTORSR01EY027387 · NEI · WASHINGTON UNIVERSITY · PI CHEN, JEANNIE, KEFALOV, VLADIMIR JIVKOV · 2017 to 2020
$1.4MAssessment of Retinal Function in Health and Disease From Mouse To HumanR00EY026651 · NEI · UNIVERSITY OF UTAH · PI VINBERG, FRANS · 2017 to 2019
$722kEnhancing Metabolic Features that Promote Photoreceptor SurvivalR21EY028645 · NEI · UNIVERSITY OF WASHINGTON · PI BROCKERHOFF, SUSAN E · 2018 to 2019
$440kASSESSMENT OF RETINAL FUNCTION IN HEALTH AND DISEASE FROM MOUSE TO HUMANK99EY026651 · NEI · WASHINGTON UNIVERSITY · PI VINBERG, FRANS · 2016 to 2017
$190kUnderstanding the role of cytosolic NADH production in maintaining aerobic glycolysis in the retinaF31EY031165 · NEI · UNIVERSITY OF WASHINGTON · PI BISBACH, CELIA · 2020 to 2021
$76kBINDING OF EXPRESSED ARRESTIN TO RHODOPSINF32EY006641 · NEI · UNIVERSITY OF FLORIDA · PI POPP, MICHAEL P · 1995 to 1997
–NEI NIH HHS EY026651NEI NIH HHS F31 EY031165NEI NIH HHS F32 EY006641NEI NIH HHS K99 EY026651NEI NIH HHS P30 EY002687NEI NIH HHS R00 EY026651NEI NIH HHS R01 EY006641NEI NIH HHS R01 EY017863NEI NIH HHS R01 EY026020NEI NIH HHS R01 EY027387NEI NIH HHS R01 EY030912NEI NIH HHS R21 EY028645NIH HHS EY026020NIH HHS EY026675NIH HHS EY027387NIH HHS EY06641NIH HHS F31EY031165
Abstract
Rods and cones use intracellular Ca
Indexed as
AnimalsBiological TransportCalciumCalcium ChannelsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial Membrane Transport ProteinsPhotoreceptor CellsRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsSodium-Calcium ExchangerZebrafishCalciumCalcium Channelsmitochondrial calcium uniporterMitochondrial Membrane Transport Proteinspotassium-dependent sodium-calcium exchangerSodium-Calcium ExchangerZebrafish Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.