ArticleScientific reports2020
Transcriptomic analysis reveals dynamic molecular changes in skin induced by mechanical forces secondary to tissue expansion.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Divergent effects of topical deferoxamine treatment on skin and cancer cells uncovers its potential as a safe radioprotective agent in oncological applications.Cancer cell international · 2026Article
- The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth.Nature communications · 2025Article
- Non-monotonic response of macrophages to mechanical stretch impacts skin wound healing.Cellular & molecular biology letters · 2025Article
- Predictive Modeling of Human Skin Deformation and Growth During Tissue Expansion in Postmastectomy Breast Reconstruction.Journal of biomechanical engineering · 2025Article
- Hippo Pathway Regulates Cell Proliferation in Skin Epidermis Exposed to Mechanical Forces.Journal of cellular and molecular medicine · 2025Article
- Development and calibration of digital twins for human skin growth in tissue expansion.Acta biomaterialia · 2025Article
- Skin Stretching Techniques: A Review of Clinical Application in Wound Repair.Plastic and reconstructive surgery. Global open · 2024Article
- Tissue expansion mitigates radiation-induced skin fibrosis in a porcine model.Acta biomaterialia · 2024Article
- Characterization of macrophages associated with human skin models exposed to UV radiation.Communications biology · 2024Article
- Hair follicle stem cells promote epidermal regeneration under expanded condition.Frontiers in physiology · 2024Review
- The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration.Biomolecules · 2023Review
- The regulation mechanism of different hair types in inner Mongolia cashmere goat based on PI3K-AKT pathway and FGF21.Journal of animal science · 2022Article
- Biological Cover Mitigates Disruption of the Dermal Structure in Mechanically Expanded Skin in a Porcine Model.International journal of molecular sciences · 2022Article
- Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion.International journal of molecular sciences · 2022Review
- Langerhans cells and SFRP2/Wnt/beta-catenin signalling control adaptation of skin epidermis to mechanical stretching.Journal of cellular and molecular medicine · 2022Article
- Bayesian calibration of a computational model of tissue expansion based on a porcine animal model.Acta biomaterialia · 2022Article
- Single-Cell Transcriptomics Uncover Key Regulators of Skin Regeneration in Human Long-Term Mechanical Stretch-Mediated Expansion Therapy.Frontiers in cell and developmental biology · 2022Article
- Identification of Common Hub Genes in Human Dermal Fibroblasts Stimulated by Mechanical Stretch at Both the Early and Late Stages.Frontiers in surgery · 2022Article
- Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch.Frontiers in genetics · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Tissue expansion procedures (TE) utilize mechanical forces to induce skin growth and regeneration. While the impact of quick mechanical stimulation on molecular changes in cells has been studied extensively, there is a clear gap in knowledge about sequential biological processes activated during long-term stimulation of skin in vivo. Here, we present the first genome-wide study of transcriptional changes in skin during TE, starting from 1 h to 7 days of expansion. Our results indicate that mechanical forces from a tissue expander induce broad molecular changes in gene expression, and that these changes are time-dependent. We revealed hierarchical changes in skin cell biology, including activation of an immune response, a switch in cell metabolism and processes related to muscle contraction and cytoskeleton organization. In addition to known mechanoresponsive genes (TNC, MMPs), we have identified novel candidate genes (SFRP2, SPP1, CCR1, C2, MSR1, C4A, PLA2G2F, HBB), which might play crucial roles in stretched-induced skin growth. Understanding which biological processes are affected by mechanical forces in TE is important for the development of skin treatments to maximize the efficacy and minimize the risk of complications during expansion procedures.
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Registered trials
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