Evidence map›Paper›PMID 32994329›Full record

ArticlemBio2020

Adaptation of Arginine Synthesis among Uropathogenic Branches of the Escherichia coli Phylogeny Reveals Adjustment to the Urinary Tract Habitat.

Michael E Hibbing, Karen W Dodson, Vasilios Kalas, Swaine L Chen, Scott J Hultgren

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Evaluation ofFrontiers in veterinary science · 2026
    Article
  4. Article
  5. Arginine at the host-pathogen interface.Infection and immunity · 2025
    Review
  6. Article
  7. Emerging roles for ABC transporters as virulence factors in uropathogenicProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. "Omics" Technologies - What Have They Told Us About UropathogenicFrontiers in cellular and infection microbiology · 2022
    Review
  13. Gene-gene relationships in anMicrobial genomics · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Michael E HibbingDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.
Karen W DodsonDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.
Vasilios KalasDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.
Swaine L ChenDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and Genome Institute of Singapore, Singapore slchen@gis.a-star.edu.sg hultgren@wustl.edu.ORCID 0000-0002-0107-2861
Scott J HultgrenDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA slchen@gis.a-star.edu.sg hultgren@wustl.edu.
Washington University in St. Louis · USNational University of Singapore · SG

Funding

pan-Genome of E.coli in the bladder and gut of women with recurrent UTIP50DK064540 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2002 to 2017
$17.9M
Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
PATHOGENIC FIBER FORMATION IN BACTERIA: STRUCTURAL BASISR01AI048689 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2020
$7.6M
Pathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9M
NIAID NIH HHS R01 AI048689NIAID NIH HHS R37 AI048689NIAID NIH HHS T32 AI007172NIDDK NIH HHS P50 DK064540NIDDK NIH HHS R01 DK051406
6 · The paper itself

Abstract

Urinary tract infections (UTIs) are predominantly caused by uropathogenic

Indexed as

Adaptation, PhysiologicalEvolution, MolecularPhylogenyAnimalsArginineEscherichia coli InfectionsEscherichia coli ProteinsFemaleGenetic FitnessMetabolic Networks and PathwaysMiceMice, Inbred C3HUrinary TractUropathogenic Escherichia coliVirulenceArginineEscherichia coli Proteinsarginine metabolismEscherichia colipositive selectionurinary tract infection

Identifiers

PMID32994329
PMCPMC7527732
OpenAlexW3091290690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.