Evidence map›Paper›PMID 32994318›Full record

ArticleDisease models & mechanisms2020

Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome.

Gabriel E Matos-Rodrigues, Pedro B Tan, Maurício Rocha-Martins, Clara F Charlier, Anielle L Gomes, Felipe Cabral-Miranda, Paulius Grigaravicius, Thomas G Hofmann, Pierre-Olivier Frappart, Rodrigo A P Martins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Gabriel E Matos-RodriguesPrograma de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941902, Brazil.ORCID 0000-0003-4085-7810
Pedro B TanPrograma de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941902, Brazil.ORCID 0000-0001-9790-9568
Maurício Rocha-MartinsMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.
Clara F CharlierPrograma de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941902, Brazil.
Anielle L GomesPrograma de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941902, Brazil.
Felipe Cabral-MirandaPrograma de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941902, Brazil.ORCID 0000-0003-4390-2760
Paulius GrigaraviciusDeutsches Krebsforschungszentrum, 69120 Heidelberg, Germany.
Thomas G HofmannInstitute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, 55131 Germany.
Pierre-Olivier FrappartInstitute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, 55131 Germany.ORCID 0000-0002-8142-3878
Rodrigo A P MartinsPrograma de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941902, Brazil rodrigo.martins@icb.ufrj.br.ORCID 0000-0002-8420-6991
Universidade Federal do Rio de Janeiro · BRJohannes Gutenberg University Mainz · DEGerman Cancer Research Center · DEMax Planck Institute of Molecular Cell Biology and Genetics · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutually dependent partners

Indexed as

Abnormalities, MultipleAdaptor Proteins, Signal TransducingAnimalsApoptosisBlindnessCell DeathCell ProliferationDisease Models, AnimalDNA-Binding ProteinsDNA DamageEmbryo, MammalianEmbryonic DevelopmentMiceNerve DegenerationNeurogenesisPhotoreceptor Cells, VertebrateAdaptor Proteins, Signal TransducingAtrip protein, mouseDNA-Binding ProteinsTumor Suppressor Protein p53ApoptosisDNA damage responseNeurodegenerationNeurodevelopmentPhotoreceptorVisual system development

Identifiers

PMID32994318
PMCPMC7648607
OpenAlexW3084245009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.