Evidence map›Paper›PMID 32994185›Full record

ArticleBiology open2020

Age-dependent degeneration of an identified adult leg motor neuron in a

Anthony Agudelo, Victoria St Amand, Lindsey Grissom, Danielle Lafond, Toni Achilli, Asli Sahin, Robert Reenan, Geoff Stilwell

Open access · goldAbstract read
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Frontiers in neuroscience · 2023
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anthony AgudeloDepartment of Biology, Rhode Island College, 600 Mt. Pleasant Ave., Providence, RI, 02908 USA.
Victoria St AmandDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912 USA.
Lindsey GrissomDepartment of Biology, Rhode Island College, 600 Mt. Pleasant Ave., Providence, RI, 02908 USA.
Danielle LafondDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912 USA.
Toni AchilliDepartment of Biology, Rhode Island College, 600 Mt. Pleasant Ave., Providence, RI, 02908 USA.
Asli SahinDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912 USA.
Robert ReenanDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912 USA.
Geoff StilwellDepartment of Biology, Rhode Island College, 600 Mt. Pleasant Ave., Providence, RI, 02908 USA gstilwell@ric.edu.ORCID 0000-0001-5696-6953
Brown University · USProvidence College · US

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Bongsup P Cho · 2012 to 2026
$63.6M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Predoctoral Training in the Molecular Biology of AgingT32AG041688 · NIA · BROWN UNIVERSITY · PI NICOLA NERETTI, John M Sedivy · 2012 to 2026
$3.5M
NIA NIH HHS T32 AG041688NIGMS NIH HHS P20 GM103430NIH HHS P40 OD018537
6 · The paper itself

Abstract

Mutations in superoxide dismutase 1 (SOD1) cause familial amyotrophic lateral sclerosis (ALS) in humans. ALS is a neurodegenerative disease characterized by progressive motor neuron loss leading to paralysis and inevitable death in affected individuals. Using a gene replacement strategy to introduce disease mutations into the orthologous

Indexed as

AgingAmyotrophic Lateral SclerosisAnimalsAnimals, Genetically ModifiedAxonsDisease Models, AnimalDisease SusceptibilityDrosophila ProteinsFluorescent Antibody TechniqueGanglia, SpinalGenetic Predisposition to DiseaseHomozygoteMotor NeuronsMutationNerve DegenerationNeuromuscular JunctionDrosophila ProteinsSod1 protein, DrosophilaSuperoxide DismutaseALSDrosophila disease modelNeurodegenerationNeuromuscular junctionSuperoxide dismutase

Identifiers

PMID32994185
PMCPMC7595701
OpenAlexW3091426471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.