Evidence map›Paper›PMID 32994166›Full record

ArticleDevelopment (Cambridge, England)2020

Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway.

Hannah K Vanyai, Fabrice Prin, Oriane Guillermin, Bishara Marzook, Stefan Boeing, Alexander Howson, Rebecca E Saunders, Thomas Snoeks, Michael Howell, Timothy J Mohun and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Mechanobiology of the Hippo-YAP Signaling Network.Cold Spring Harbor perspectives in biology · 2026
    Article
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  7. Article
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  10. Review
  11. Review
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Hannah K VanyaiThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Fabrice PrinThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Oriane GuillerminThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Bishara MarzookThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Stefan BoeingThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Alexander HowsonThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Rebecca E SaundersThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Thomas SnoeksThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Michael HowellThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Timothy J MohunThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK.
Barry ThompsonThe Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK barry.thompson@anu.edu.au.
The Francis Crick Institute · GBAustralian National University · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

Cancer Research UK FC001180Medical Research Council FC001180Wellcome Trust FC001180
6 · The paper itself

Abstract

The Hippo-YAP/TAZ pathway is an important regulator of tissue growth, but can also control cell fate or tissue morphogenesis. Here, we investigate the function of the Hippo pathway during the development of cartilage, which forms the majority of the skeleton. Previously, YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation and differentiation. We find that,

Indexed as

MorphogenesisAdaptor Proteins, Signal TransducingAnimalsBone and BonesCartilageCell Cycle ProteinsCell NucleusCell ProliferationChondrocytesCleft PalateExtracellular MatrixGene Expression Regulation, DevelopmentalGrowth PlateHippo Signaling PathwayMiceMice, Inbred C57BLAdaptor Proteins, Signal TransducingCell Cycle ProteinsLats1 protein, mouseLATS2 protein, mouseProtein Serine-Threonine KinasesTrans-ActivatorsTumor Suppressor ProteinsWwtr1 protein, mouseYap1 protein, mouseYAP-Signaling ProteinsCartilageHippo pathwayMouse embryoTAZYAP

Identifiers

PMID32994166
PMCPMC7673359
OpenAlexW3089356965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.